Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery

被引：33

作者：

Liu, Huan ^{[1
,2
]}

Zhang, Ningbo ^{[1
,2
]}

Wan, Debin ^{[1
,2
]}

Cui, Meng ^{[1
]}

Liu, Zhiqiang ^{[1
]}

Liu, Shuying ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, 5625 Renmin St, Changchun 130022, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

CLINICAL PROTEOMICS | 2014年 / 11卷

基金：

中国国家自然科学基金;

关键词：

Mass spectrometry; Glycoproteins; Cancer biomarker; ELECTRON DETACHMENT DISSOCIATION; N-LINKED GLYCOPROTEINS; NANO-LC-MS/MS; STRUCTURAL-CHARACTERIZATION; PROTEIN GLYCOSYLATION; QUANTITATIVE-ANALYSIS; LIVER-CANCER; IDENTIFICATION; SERUM; GLYCANS;

D O I：

10.1186/1559-0275-11-14

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods for analysis of aberrant glycoproteins associated with diseases. Mass spectrometry (MS) has become a powerful tool for glycoprotein analysis. Especially, tandem mass spectrometry can provide highly informative fragments for structural identification of glycoproteins. This review provides an overview of the development of MS technologies and their applications in identification of abnormal glycoproteins and glycans in human serum to screen cancer biomarkers in recent years.

引用

页数：9

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