Mass spectrometry-based analysis of glycoproteins and its clinical applications in cancer biomarker discovery

被引：33
|
作者：
Liu, Huan [1 ,2 ]
Zhang, Ningbo [1 ,2 ]
Wan, Debin [1 ,2 ]
Cui, Meng [1 ]
Liu, Zhiqiang [1 ]
Liu, Shuying [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun Ctr Mass Spectrometry, 5625 Renmin St, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
CLINICAL PROTEOMICS | 2014年 / 11卷
基金：
中国国家自然科学基金;
关键词：
Mass spectrometry; Glycoproteins; Cancer biomarker; ELECTRON DETACHMENT DISSOCIATION; N-LINKED GLYCOPROTEINS; NANO-LC-MS/MS; STRUCTURAL-CHARACTERIZATION; PROTEIN GLYCOSYLATION; QUANTITATIVE-ANALYSIS; LIVER-CANCER; IDENTIFICATION; SERUM; GLYCANS;
D O I：
10.1186/1559-0275-11-14
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Glycosylation is one of the most important posttranslational modifications of proteins and plays essential roles in various biological processes. Aberration in the glycan moieties of glycoproteins is associated with many diseases. It is especially critical to develop the rapid and sensitive methods for analysis of aberrant glycoproteins associated with diseases. Mass spectrometry (MS) has become a powerful tool for glycoprotein analysis. Especially, tandem mass spectrometry can provide highly informative fragments for structural identification of glycoproteins. This review provides an overview of the development of MS technologies and their applications in identification of abnormal glycoproteins and glycans in human serum to screen cancer biomarkers in recent years.
引用
收藏
页数：9
相关论文
共 50 条
  • [21] Variant biomarker discovery using mass spectrometry-based proteogenomics
    Reilly, Luke
    Seddighi, Sahba
    Singleton, Andrew B.
    Cookson, Mark R.
    Ward, Michael E.
    Qi, Yue A.
    FRONTIERS IN AGING, 2023, 4
  • [22] Mass spectrometry-based metabolomics: applications to biomarker and metabolic pathway research
    Zhang, Aihua
    Sun, Hui
    Yan, Guangli
    Wang, Ping
    Wang, Xijun
    BIOMEDICAL CHROMATOGRAPHY, 2016, 30 (01) : 7 - 12
  • [23] Mass spectrometry-based analysis of IgG glycosylation and its applications
    Liu, Xuejiao
    Sun, Zhenyu
    Li, Zhonghua
    Zhang, Ying
    Lu, Haojie
    INTERNATIONAL JOURNAL OF MASS SPECTROMETRY, 2022, 474
  • [24] Mass spectrometry-based phosphoproteomics in clinical applications
    Wu, Xiaofeng
    Liu, Yi-Kai
    Iliuk, Anton B.
    Tao, W. Andy
    TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2023, 163
  • [25] Mass spectrometry-based antigen discovery for cancer immunotherapy
    Bassani-Sternberg, Michal
    Coukos, George
    CURRENT OPINION IN IMMUNOLOGY, 2016, 41 : 9 - 17
  • [26] Mass Spectrometry-Based Proteomics and Peptidomics for Biomarker Discovery in Neurodegenerative Diseases
    Wei, Xin
    Li, Lingjun
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2009, 2 (02): : 132 - 148
  • [27] Mass Spectrometry-Based Glycoproteomics and Prostate Cancer
    Gabriele, Caterina
    Prestagiacomo, Licia E.
    Cuda, Giovanni
    Gaspari, Marco
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (10)
  • [28] PHOSPHOLIPIDS AS CANCER BIOMARKERS: MASS SPECTROMETRY-BASED ANALYSIS
    Bandu, Raju
    Mok, Hyuck Jun
    Kim, Kwang Pyo
    MASS SPECTROMETRY REVIEWS, 2018, 37 (02) : 107 - 138
  • [29] Application of multiple statistical tests to enhance mass spectrometry-based biomarker discovery
    Tan, Niclas C.
    Fisher, Wayne G.
    Rosenblatt, Kevin P.
    Garner, Harold R.
    BMC BIOINFORMATICS, 2009, 10
  • [30] Mass Spectrometry-based Strategies and Methods for N-linked Intact Glycopeptide Analysis
    Zhu Bo-Jing
    Zhi Yuan
    Sun Shi-Sheng
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2017, 44 (10) : 821 - 829
12345