Two polymorphs and one hydrate of a molecular salt involving phenazopyridine and salicylic acid

被引：16

作者：

Tao, Qian ^{[1
]}

Chen, Jia-Mei ^{[1
]}

Lu, Tong-Bu ^{[2
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, MOE Key Lab Bioinorgan & Synthet Chem, State Key Lab Optoelect Mat & Technol, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

CRYSTENGCOMM | 2013年 / 15卷 / 39期

关键词：

COCRYSTALS; SOLUBILITY; STABILITY;

D O I：

10.1039/c3ce41188e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two anhydrous polymorphs (AH-I, AH-II) and one monohydrate (MH) of a molecular salt involving phenazopyridine and salicylic acid, are reported. The charge-assisted N-H center dot center dot center dot O hydrogen bond provides the main driving force for the direct binding of the two compounds. AH-I is the stable anhydrous form with a low hygroscopicity, a high solubility and a simple preparation method.

引用

页码：7852 / 7855

页数：4

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