Two polymorphs and one hydrate of a molecular salt involving phenazopyridine and salicylic acid

被引:16
|
作者
Tao, Qian [1 ]
Chen, Jia-Mei [1 ]
Lu, Tong-Bu [2 ]
机构
[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, MOE Key Lab Bioinorgan & Synthet Chem, State Key Lab Optoelect Mat & Technol, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
来源
CRYSTENGCOMM | 2013年 / 15卷 / 39期
关键词
COCRYSTALS; SOLUBILITY; STABILITY;
D O I
10.1039/c3ce41188e
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Two anhydrous polymorphs (AH-I, AH-II) and one monohydrate (MH) of a molecular salt involving phenazopyridine and salicylic acid, are reported. The charge-assisted N-H center dot center dot center dot O hydrogen bond provides the main driving force for the direct binding of the two compounds. AH-I is the stable anhydrous form with a low hygroscopicity, a high solubility and a simple preparation method.
引用
收藏
页码:7852 / 7855
页数:4
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