Bauhinia forficata in the treatment of diabetes mellitus: a patent review

被引:22
作者
Cardoso de Souza, Barbara Veronica [1 ]
dos Reis Moreira Araujo, Regilda Saraiva [1 ]
Silva, Oskar Almeida [2 ]
Faustino, Lucas Costa [3 ]
Beserra Goncalves, Maria Fabricia [1 ]
Dos Santos, Mirian Lima [4 ]
Souza, Grasielly Rocha [4 ]
Rocha, Lindalva Moura [5 ]
Sousa Cardoso, Monica Larissa [1 ]
Cunha Nunes, Livio Cesar [4 ]
机构
[1] Univ Fed Piaui, Nutr Dept, Piaui, Brazil
[2] Univ Fed Piaui, Postgrad Program Biotechnol, Piaui, Brazil
[3] Univ Fed Piaui, Dept Chem, Piaui, Brazil
[4] Univ Fed Piaui, Dept Pharm, Piaui, Brazil
[5] Univ Fed Piaui, Postgrad Program Mat Sci, Piaui, Brazil
关键词
Bauhinia forficata; diabetes mellitus; phytotherapy; Flavonoids; kaempferol; insulin resistance; DIETARY POLYPHENOLS; OXIDATIVE STRESS; FLAVONOID INTAKE; GLYCEMIC VARIABILITY; INSULIN-RESISTANCE; PLANT FLAVONOIDS; MEDICINAL-PLANTS; HEART-DISEASE; ANTIOXIDANT; RISK;
D O I
10.1080/13543776.2018.1409208
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Introduction: Diabetes Mellitus has been considered an epidemic by the World Health Organization, with a high risk of morbidity and mortality. The treatment of this pathology consists in glycemic control, which can be done by oral hypoglycemic agents, insulin therapy, dietary guidance, regular physical activity, and psychosocial support. In addition, other adjuvant treatments are employed, such as phytotherapic, and one of the most used plants is Bauhinia forficata. Areas covered: In the current review, patents using Bauhinia forficata for the Diabetes Mellitus treatment have been analyzed. There were 03 patents in WIPO, 01 in Espacenet, 01 in USPTO, and 02 in INPI. Expert opinion: Patents on the adjuvant treatment of Diabetes Mellitus by Bauhinia forficata are discussed. Although there are some phytotherapy products containing this medicinal plant which has hypoglycemic effect here is still a need for the development of more products based on natural resources, for the treatment of this pathology, without side effects and with other benefits, to assist in the glycemia control in diabetic patients, and to improve their quality of life.
引用
收藏
页码:129 / 138
页数:10
相关论文
共 100 条
[1]  
[Anonymous], CLIN PRACT GUID DIAB
[2]  
[Anonymous], 2008, PLANTAS MED BRASIL N
[3]   Patents of drugs extracted from Brazilian medicinal plants [J].
Balbani, Aracy P. S. ;
Silva, Dulce H. S. ;
Montovani, Jair C. .
EXPERT OPINION ON THERAPEUTIC PATENTS, 2009, 19 (04) :461-473
[4]   Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells [J].
Bast, A ;
Wolf, G ;
Oberbäumer, I ;
Walther, R .
DIABETOLOGIA, 2002, 45 (06) :867-876
[5]   N-monomethyl-arginine and nicotinamide prevent streptozotocin-induced double strand DNA break formation in pancreatic rat islets [J].
Bedoya, FJ ;
Solano, F ;
Lucas, M .
EXPERIENTIA, 1996, 52 (04) :344-347
[6]   Polyphenols and inflammation: basic interactions [J].
Biesalski, Hans K. .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2007, 10 (06) :724-728
[7]  
Brown JE, 1998, BIOCHEM J, V330, P1173
[8]   Intramuscular heat shock protein 72 and heme oxygenase-1 mRNA are reduced in patients with type 2 diabetes - Evidence that insulin resistance is associated with a disturbed antioxidant defense mechanism [J].
Bruce, CR ;
Carey, AL ;
Hawley, JA ;
Febbraio, MA .
DIABETES, 2003, 52 (09) :2338-2345
[9]   Postprandial Blood Glucose Predicts Cardiovascular Events and All-Cause Mortality in Type 2 Diabetes in a 14-Year Follow-Up [J].
Cavalot, Franco ;
Pagliarino, Andrea ;
Valle, Manuela ;
Di Martino, Leonardo ;
Bonomo, Katia ;
Massucco, Paola ;
Anfossi, Giovanni ;
Trovati, Mariella .
DIABETES CARE, 2011, 34 (10) :2237-2243
[10]   Flavonoids: Prospective Drug Candidates [J].
Cazarolli, Luisa Helena ;
Zanatta, Leila ;
Alberton, Elga Heloisa ;
Reis Bonorino Figueiredo, Maria Santos ;
Folador, Poliane ;
Damazio, Rosangela Guollo ;
Pizzolatti, Moacir Geraldo ;
Mena Barreto Silva, Fatima Regina .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2008, 8 (13) :1429-1440