Analysis of US FDA-Approved Drugs Containing Sulfur Atoms

被引：884
作者：
Scott, Kevin A. [1 ,2 ]
Njardarson, Jon T. [1 ]
机构：
[1] Univ Arizona, Dept Chem & Biochem, Tucson, AZ 85721 USA
[2] Univ Arizona, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA
来源：
TOPICS IN CURRENT CHEMISTRY | 2018年 / 376卷 / 01期
基金：
美国国家科学基金会;
关键词：
Sulfonamide; Thioether; Sulfoxide; Sulfone; Sulfate; Sulfur heterocycle; P2Y(12) RECEPTOR; MANAGEMENT; DOPAMINE; MECHANISMS; CHEMISTRY; PROTEASE; DISEASE; ANALOGS; FAMILY;
D O I：
10.1007/s41061-018-0184-5
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this review, we discuss all sulfur-containing FDA-approved drugs and their structures. The second section of the review is dedicated to structural analysis and is divided into 14 subsections, each focusing on one type of sulfur-containing moiety. A concise graphical representation of each class features drugs that are organized on the basis of structural similarity, evolutionary relevance, and medical indication. This review offers a unique and comprehensive overview of the structural features of all sulfur-containing FDA-approved drugs to date.
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页数：34
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