Neurotransmission and neurotoxicity by nitric oxide, catecholamines, and glutamate: Unifying themes of reactive oxygen species and electron transfer

被引：37
作者：
Jacintho, JD [1 ]
Kovacic, P [1 ]
机构：
[1] San Diego State Univ, Dept Chem, San Diego, CA 92182 USA
来源：
CURRENT MEDICINAL CHEMISTRY | 2003年 / 10卷 / 24期
关键词：
nitric oxide; catecholamines; glutamate; neurotransmission; neurotoxicity; oxidative stress; reactive oxygen species; electron transfer; cell signaling; antioxidants;
D O I：
10.2174/0929867033456404
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This review treats the mechanism of nitric oxide, catecholamines, and glutamate as important neurotransmitters and as neurotoxins, based on involvement of reactive oxygen species (ROS) and electron transfer (ET). ROS and ET can serve as a unifying framework for both transmission and toxicity, with ROS concentration being a crucial issue. Cell signaling, electrochemistry, antioxidants, and apoptosis are also discussed.
引用
收藏
页码：2693 / 2703
页数：11
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