Intestinal dysbacteriosis induces changes of T lymphocyte subpopulations in Peyer's patches of mice and orients the immune response towards humoral immunity

被引：11

作者：

Gao, Fei ^{[1
]}

Li, Ming ^{[1
]}

Liu, Yinhui ^{[1
]}

Gao, Chuanzhou ^{[2
]}

Wen, Shu ^{[1
]}

Tang, Li ^{[1
]}

机构：

[1] Dalian Med Univ, Dept Microecol, Dalian 116044, Peoples R China

[2] Dalian Med Univ, Cent Lab, Dalian 116044, Peoples R China

来源：

GUT PATHOGENS | 2012年 / 4卷

基金：

中国国家自然科学基金;

关键词：

Intestinal dysbacteriosis; Peyer's patches; Immune response; T lymphocytes; Cytokines; INFLAMMATORY-BOWEL-DISEASE; DIVERSITY; FLORA; DYSFUNCTION; INDUCTION; CELLS; GALT;

D O I：

10.1186/1757-4749-4-19

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The large numbers of human intestinal microorganisms have a highly co-evolved relationship with the immune system. Dysbacteriosis of intestinal microbiota induces alterations of immune responses, and is closely related to disease development. Peyer's patches are immune sensors in intestine which exert essential functions during development of inflammatory disease. However, interactions between commensal bacteria and PPs have been poorly characterized. In this study, changes of lymphocyte subpopulations and production of cytokines in PPs of mice with intestinal dysbacteriosis were investigated. The ceftriaxone-induced dysbacteriosis caused a notable change in populations of T lymphocytes, their subpopulations in PPs and expressions of various cytokines. Our results suggest intestinal dysbacteriosis in mice reduces immune tolerance in PPs and orients immune response towards humoral immunity.

引用

页数：3

共 10 条

[1] Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species [J].

Atarashi, Koji ;

Tanoue, Takeshi ;

Shima, Tatsuichiro ;

Imaoka, Akemi ;

Kuwahara, Tomomi ;

Momose, Yoshika ;

Cheng, Genhong ;

Yamasaki, Sho ;

Saito, Takashi ;

Ohba, Yusuke ;

Taniguchi, Tadatsugu ;

Takeda, Kiyoshi ;

Hori, Shohei ;

Ivanov, Ivaylo I. ;

Umesaki, Yoshinori ;

Itoh, Kikuji ;

Honda, Kenya .

SCIENCE, 2011, 331 (6015) :337-341

[2] Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (II) [J].

Chandran, P ;

Safthaporn, S ;

Robins, A ;

Eremin, O .

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, 2003, 1 (03) :125-136

[3] Inflammatory bowel disease: dysfunction of GALT and gut bacterial flora (I) [J].

Chandran, P ;

Satthaporn, S ;

Robins, A ;

Eremin, O .

SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND, 2003, 1 (02) :63-75

[4] Diversity of the human intestinal microbial flora [J].

Eckburg, PB ;

Bik, EM ;

Bernstein, CN ;

Purdom, E ;

Dethlefsen, L ;

Sargent, M ;

Gill, SR ;

Nelson, KE ;

Relman, DA .

SCIENCE, 2005, 308 (5728) :1635-1638

[5] Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases [J].

Frank, Daniel N. ;

Amand, Allison L. St. ;

Feldman, Robert A. ;

Boedeker, Edgar C. ;

Harpaz, Noam ;

Pace, Norman R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (34) :13780-13785

[6] An integrated view of suppressor T cell subsets in immunoregulation [J].

Jiang, H ;

Chess, L .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (09) :1198-1208

[7] Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach [J].

Manichanh, C ;

Rigottier-Gois, L ;

Bonnaud, E ;

Gloux, K ;

Pelletier, E ;

Frangeul, L ;

Nalin, R ;

Jarrin, C ;

Chardon, P ;

Marteau, P ;

Roca, J ;

Dore, J .

GUT, 2006, 55 (02) :205-211

[8] Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease [J].

Ott, SJ ;

Musfeldt, M ;

Wenderoth, DF ;

Hampe, J ;

Brant, O ;

Fölsch, UR ;

Timmins, KN ;

Schreiber, S .

GUT, 2004, 53 (05) :685-693

[9] Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches [J].

Spahn, TW ;

Herbst, H ;

Rennert, PD ;

Lügering, N ;

Maaser, C ;

Kraft, M ;

Fontana, A ;

Weiner, HL ;

Domschke, W ;

Kucharzik, T .

AMERICAN JOURNAL OF PATHOLOGY, 2002, 161 (06) :2273-2282

[10] Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus [J].

Watanabe, N ;

Wang, YH ;

Lee, HK ;

Ito, T ;

Wang, YH ;

Cao, W ;

Liu, YJ .

NATURE, 2005, 436 (7054) :1181-1185

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