RNA-Binding Proteins in Cancer: Old Players and New Actors

被引：575

作者：

Pereira, Bruno ^{[1
,2
]}

Billaud, Marc ^{[3
]}

Almeida, Raquel ^{[1
,2
,4
,5
]}

机构：

[1] Univ Porto, Inst Res & Innovat Hlth I3S, P-4200135 Oporto, Portugal

[2] Univ Porto IPATIMUP, Inst Mol Pathol & Immunol, P-4200465 Oporto, Portugal

[3] Univ Claude Bernard Lyon 1, Clin & Expt Model Lymphomagenesis, INSERM, Unite 1052,CNRS,Unite 5286,Ctr Leon Berard,Ctr Re, Lyon, France

[4] Univ Porto, Fac Med, P-4200319 Oporto, Portugal

[5] Univ Porto, Biol Dept, Fac Sci, P-4169007 Oporto, Portugal

来源：

TRENDS IN CANCER | 2017年 / 3卷 / 07期

关键词：

TRANSCRIPTOME-WIDE IDENTIFICATION; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR GENE; SPLICING FACTOR SRSF1; CLEAVAGE FACTOR-I; MESSENGER-RNA; C-MYC; POSTTRANSCRIPTIONAL REGULATION; TRANSLATIONAL CONTROL; MICRORNA BIOGENESIS;

D O I：

10.1016/j.trecan.2017.05.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RNA-binding proteins (RBPs) are key players in post-transcriptional events. The combination of versatility of their RNA-binding domains with structural flexibility enables RBPs to control the metabolism of a large array of transcripts. Perturbations in RBP-RNA networks activity have been causally associated with cancer development, but the rational framework describing these contributions remains fragmented. We review here the evidence that RBPs modulate multiple cancer traits, emphasize their functional diversity, and assess future trends in the study of RBPs in cancer

引用

页码：506 / 528

页数：23

共 234 条

[1] Posttranscriptional orchestration of an anti-apoptotic program by HuR [J].

Abdelmohsen, Kotb ;

Lal, Ashish ;

Kim, Hyeon Ho ;

Gorospe, Myriam .

CELL CYCLE, 2007, 6 (11) :1288-1292

[2] Phosphorylation of HuR by Chk2 regulates SIRT1 expression [J].

Abdelmohsen, Kotb ;

Pullmann, Rudolf, Jr. ;

Lai, Ashish ;

Kim, Hyeon Ho ;

Galban, Stefanie ;

Yang, Xiaoling ;

Blethrow, Justin D. ;

Walker, Mark ;

Shubert, Jonathan ;

Gillespie, David A. ;

Furneaux, Henry ;

Gorospe, Myriam .

MOLECULAR CELL, 2007, 25 (04) :543-557

[3] RNA-binding protein AUF1 represses Dicer expression [J].

Abdelmohsen, Kotb ;

Tominaga-Yamanaka, Kumiko ;

Srikantan, Subramanya ;

Yoon, Je-Hyun ;

Kang, Min-Ju ;

Gorospe, Myriam .

NUCLEIC ACIDS RESEARCH, 2012, 40 (22) :11531-11544

[4] Posttranscriptional regulation of cancer traits by HuR [J].

Abdelmohsen, Kotb ;

Gorospe, Myriam .

WILEY INTERDISCIPLINARY REVIEWS-RNA, 2010, 1 (02) :214-229

[5] miR-519 suppresses tumor growth by reducing HuR levels [J].

Abdelmohsen, Kotb ;

Kim, Mihee M. ;

Srikantan, Subramanya ;

Mercken, Evi M. ;

Brennan, Sarah E. ;

Wilson, Gerald M. ;

de Cabo, Rafael ;

Gorospe, Myriam .

CELL CYCLE, 2010, 9 (07) :1354-1359

[6] miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels [J].

Abdelmohsen, Kotb ;

Srikantan, Subramanya ;

Kuwano, Yuki ;

Gorospe, Myriam .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (51) :20297-20302

[7] Comparative genomics and evolution of proteins involved in RNA metabolism [J].

Anantharaman, V ;

Koonin, EV ;

Aravind, L .

NUCLEIC ACIDS RESEARCH, 2002, 30 (07) :1427-1464

[8] The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation [J].

Anczukow, Olga ;

Rosenberg, Avi Z. ;

Akerman, Martin ;

Das, Shipra ;

Zhan, Lixing ;

Karni, Rotem ;

Muthuswamy, Senthil K. ;

Krainer, Adrian R. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2012, 19 (02) :220-228

[9] The RNA binding protein Sam68 is acetylated in tumor cell lines, and its acetylation correlates with enhanced RNA binding activity [J].

Babic, I ;

Jakymiw, A ;

Fujita, DJ .

ONCOGENE, 2004, 23 (21) :3781-3789

[10] Mex3a Marks a Slowly Dividing Subpopulation of Lgr5+Intestinal Stem Cells [J].

Barriga, Francisco M. ;

Montagni, Elisa ;

Mana, Miyeko ;

Mendez-Lago, Maria ;

Hernando-Momblona, Xavier ;

Sevillano, Marta ;

Guillaumet-Adkins, Amy ;

Rodriguez-Esteban, Gustavo ;

Buczacki, Simon J. A. ;

Gut, Marta ;

Heyn, Holger ;

Winton, Douglas J. ;

Yilmaz, Omer H. ;

Stephan-Otto Attolini, Camille ;

Gut, Ivo ;

Batlle, Eduard .

CELL STEM CELL, 2017, 20 (06) :801-+

← 1 2 3 4 5 6 7 8 9 10 →