Exosomal Transfer of Vasorin Expressed in Hepatocellular Carcinoma Cells Promotes Migration of Human Umbilical Vein Endothelial Cells

被引：92

作者：

Huang, Aixue ^{[1
]}

Dong, Jie ^{[1
]}

Li, Shaohua ^{[1
]}

Wang, Chaonan ^{[1
]}

Ding, Hongmei ^{[1
]}

Li, Hui ^{[1
]}

Su, Xueting ^{[1
]}

Ge, Xingfeng ^{[1
]}

Sun, Leqiao ^{[1
]}

Bai, Chenjun ^{[1
]}

Shen, Xuelian ^{[1
]}

Fang, Tao ^{[1
]}

Li, Jie ^{[1
]}

Shao, Ningsheng ^{[1
]}

机构：

[1] Beijing Inst Basic Med Sci, Beijing 100850, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2015年 / 11卷 / 08期

关键词：

Vasorin; exosomes; endocytosis; angiogenesis; tumor metastasis; TARGET; INTERNALIZATION; BIOMARKERS; PROTEINS; GROWTH; ACID; RAT;

D O I：

10.7150/ijbs.11943

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vasorin (VASN) is a type I transmembrane protein that plays important roles in tumor development and vasculogenesis. In this paper, we showed that VASN could be a key mediator of communication between tumor cells and endothelial cells. We confirmed for the first time that HepG2-derived VASN can be transferred to human umbilical vein endothelial cells (HUVECs) via receptor mediated endocytosis of exosomes, at least in part through HSPGs. The HepG2-derived VASN containing exosomes promote migration of recipient HUVECs cells. Our results identify a novel pathway by which a functional protein expressed in tumor cells affects the biological fate of endothelial cells via exosomes.

引用

页码：961 / 969

页数：9

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