Intermittent or sustained systemic inflammation and the preterm brain

被引：114

作者：

Dammann, Olaf ^{[1
,2
,3
]}

Leviton, Alan ^{[4
]}

机构：

[1] Tufts Univ, Sch Med, Dept Publ Hlth & Community Med, Boston, MA 02111 USA

[2] Floating Hosp Children, Div Newborn Med, Dept Neurol, Tufts Med Ctr, Boston, MA USA

[3] Hannover Med Sch, Perinatal Neuroepidemiol Unit, Hannover, Germany

[4] Childrens Hosp, Neuroepidemiol Unit, Boston, MA 02115 USA

来源：

PEDIATRIC RESEARCH | 2014年 / 75卷 / 03期

基金：

美国国家卫生研究院;

关键词：

TUMOR-NECROSIS-FACTOR; CEREBRAL-PALSY; MOLECULAR-PATTERNS; HYPOXIA-ISCHEMIA; GENE-EXPRESSION; FACTOR-ALPHA; CELL-DEATH; MECHANISMS; CYTOKINES; DAMAGE;

D O I：

10.1038/pr.2013.238

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Exposure to perinatal infection and inflammation is associated with an increased risk for neonatal brain damage and developmental disabilities. In this integrated mechanism review, we discuss evidence in support of the contention that the preterm newborn is capable of intermittent or sustained systemic inflammation (ISSI), which appears to contribute more to adverse neurodevelopmental outcomes in preterm infants than does shorter duration inflammation.

引用

页码：376 / 380

页数：5

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