A novel facet of tumor suppression by p53 Induction of tumor immunogenicity

被引：8

作者：

Li, Hai ^{[1
]}

Lakshmikanth, Tadepally ^{[1
]}

Carbone, Ennio ^{[1
,2
]}

Selivanova, Galina ^{[1
]}

机构：

[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[2] Univ Catanzaro Magna Graecia, Dept Expt & Clin Med, Tumor Immunol Lab, Catanzaro, Italy

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 04期

关键词：

p53; NKG2D; ULBP2; innate immunity; cancer; CANCER; LIGANDS; STRESS; ULBP2;

D O I：

10.4161/onci.19409

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pharmacological reactivation of the p53 tumor suppressor is a promising strategy for anti-cancer therapy due to its high potential to elicit apoptosis or growth arrest in cancer cells. Recently we uncovered the mechanism of activation of the innate immune response by p53 upon its activation by small molecules.

引用

页数：3

共 10 条

[1] Chemotherapy-Induced Genotoxic Stress Promotes Sensitivity to Natural Killer Cell Cytotoxicity by Enabling Missing-Self Recognition [J].

Fine, Jason H. ;

Chen, Peter ;

Mesci, Aruz ;

Allan, David S. J. ;

Gasser, Stephan ;

Raulet, David H. ;

Carlyle, James R. .

CANCER RESEARCH, 2010, 70 (18) :7102-7113

[2] The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor [J].

Gasser, S ;

Orsulic, S ;

Brown, EJ ;

Raulet, DH .

NATURE, 2005, 436 (7054) :1186-1190

[3] Modes of p53 Regulation [J].

Kruse, Jan-Philipp ;

Gu, Wei .

CELL, 2009, 137 (04) :609-622

[4] Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2 [J].

Li, Hai ;

Lakshmikanth, Tadepally ;

Garofalo, Cinzia ;

Enge, Martin ;

Spinnler, Clemens ;

Anichini, Andrea ;

Szekely, Laszlo ;

Karre, Klas ;

Carbone, Ennio ;

Selivanova, Galina .

CELL CYCLE, 2011, 10 (19) :3346-3358

[5] Dysregulation of p53/Sp1 Control Leads to DNA Methyltransferase-1 Overexpression in Lung Cancer [J].

Lin, Ruo-Kai ;

Wu, Chiu-Yi ;

Chang, Jer-Wei ;

Juan, Li-Jung ;

Hsu, Han-Shui ;

Chen, Chih-Yi ;

Lu, Yun-Yueh ;

Tang, Yen-An ;

Yang, Yi-Chieh ;

Yang, Pan-Chyr ;

Wang, Yi-Ching .

CANCER RESEARCH, 2010, 70 (14) :5807-5817

[6] A complex barcode underlies the heterogeneous response of p53 to stress [J].

Murray-Zmijewski, Fiona ;

Slee, Elizabeth A. ;

Lu, Xin .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (09) :702-712

[7] Therapeutic targeting of p53 by small molecules [J].

Selivanova, Galina .

SEMINARS IN CANCER BIOLOGY, 2010, 20 (01) :46-56

[8] Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2 [J].

Textor, Sonja ;

Fiegler, Nathalie ;

Arnold, Annette ;

Porgador, Angel ;

Hofmann, Thomas G. ;

Cerwenka, Adelheid .

CANCER RESEARCH, 2011, 71 (18) :5998-6009

[9] Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas [J].

Xue, Wen ;

Zender, Lars ;

Miething, Cornelius ;

Dickins, Ross A. ;

Hernando, Eva ;

Krizhanovsky, Valery ;

Cordon-Cardo, Carlos ;

Lowe, Scott W. .

NATURE, 2007, 445 (7128) :656-660

[10] Inhibition of Glycolytic Enzymes Mediated by Pharmacologically Activated p53 TARGETING WARBURG EFFECT TO FIGHT CANCER [J].

Zawacka-Pankau, Joanna ;

Grinkevich, Vera V. ;

Huenten, Sabine ;

Nikulenkov, Fedor ;

Gluch, Angela ;

Li, Hai ;

Enge, Martin ;

Kel, Alexander ;

Selivanova, Galina .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (48) :41600-41615

← 1 →