Defensins of vertebrate animals

被引：587
作者：
Lehrer, RI
Ganz, T
机构：
[1] Univ Calif Los Angeles, Inst Mol Biol, Dept Med, Hlth Sci Ctr, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Dept Pathol, Hlth Sci Ctr, Los Angeles, CA 90095 USA
来源：
CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 01期
关键词：
D O I：
10.1016/S0952-7915(01)00303-X
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
During the past year, novel beta-defensins of mice and men have been identified, together with a novel defensin subfamily (the circular or 'theta' minidefensins) in primates. Insight into the evolution of defensins has been obtained from structural studies, and several mechanisms related to microbial resistance to defensins have been delineated, There is now convincing evidence that defensins augment adaptive immune responses.
引用
收藏
页码：96 / 102
页数：7
相关论文
共 53 条
[1]   The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations [J].
Agerberth, B ;
Charo, J ;
Werr, J ;
Olsson, B ;
Idali, F ;
Lindbom, L ;
Kiessling, R ;
Jörnvall, H ;
Wigzell, H ;
Gudmundsson, GH .
BLOOD, 2000, 96 (09) :3086-3093
[2]   Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria [J].
Ayabe, T ;
Satchell, DP ;
Wilson, CL ;
Parks, WC ;
Selsted, ME ;
Ouellette, AJ .
NATURE IMMUNOLOGY, 2000, 1 (02) :113-118
[3]   Mouse β-defensin 3 is an inducible antimicrobial peptide expressed in the epithelia of multiple organs [J].
Bals, R ;
Wang, XR ;
Meegalla, RL ;
Wattler, S ;
Weiner, DJ ;
Nehls, MC ;
Wilson, JM .
INFECTION AND IMMUNITY, 1999, 67 (07) :3542-3547
[4]   CD14-dependent lipopolysaccharide-induced ß-defensin-2 expression in human tracheobronchial epithelium [J].
Becker, MN ;
Diamond, G ;
Verghese, MW ;
Randell, SH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (38) :29731-29736
[5]  
Chaly YV, 2000, EUR CYTOKINE NETW, V11, P257
[6]   Cutting edge:: IFN-inducible ELR- CXC chemokines display defensin-like antimicrobial activity [J].
Cole, AM ;
Ganz, T ;
Liese, AM ;
Burdick, MD ;
Liu, L ;
Strieter, RM .
JOURNAL OF IMMUNOLOGY, 2001, 167 (02) :623-627
[7]   Inhibition of neutrophil elastase prevents cathelicidin activation and impairs clearance of bacteria from wounds [J].
Cole, AM ;
Shi, JS ;
Ceccarelli, A ;
Kim, YH ;
Park, A ;
Ganz, T .
BLOOD, 2001, 97 (01) :297-304
[8]   Inhibition of hBD-3, but not hBD-1 and hBD-2, mRNA expression by corticosteroids [J].
Duits, LA ;
Rademaker, M ;
Ravensbergen, B ;
van Sterkenburg, MAJA ;
van Strijen, E ;
Hiemstra, PS ;
Nibbering, PH .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (02) :522-525
[9]   MOUSE NEUTROPHILS LACK DEFENSINS [J].
EISENHAUER, PB ;
LEHRER, RI .
INFECTION AND IMMUNITY, 1992, 60 (08) :3446-3447
[10]   An essential amino acid induces epithelial β-defensin [J].
Fehlbaum, P ;
Rao, M ;
Zasloff, M ;
Anderson, GM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12723-12728
123456