MicroRNA and vascular smooth muscle cell phenotype: new therapy for atherosclerosis?

被引：27
|
作者：
Zhang, Chunxiang [1 ]
机构：
[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Anesthesiol, RNA & Cardiovasc Res Lab, Newark, NJ 07101 USA
来源：
GENOME MEDICINE | 2009年 / 1卷
基金：
美国国家卫生研究院;
关键词：
Phenotypic Modulation; Atherosclerotic Vascular Disease; VSMC Proliferation; Atherosclerotic Artery; Smooth Muscle Cell Phenotype;
D O I：
10.1186/gm85
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have identified that miR-145 is the most abundant miRNA in normal arteries and vascular smooth muscle cells (VSMCs), and its expression is significantly downregulated in dedifferentiated VSMCs and atherosclerotic arteries. miR-145 plays a critical role in modulating VSMC phenotype. Because phenotypic modulation of VSMCs is an initial cellular event in the development of atherosclerosis, miRNAs, and miR-145 in particular, may represent new therapeutic targets for atherosclerosis.
引用
收藏
页数：3
相关论文
共 50 条
  • [41] Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation
    Klein, Benjamin
    Destephens, Anthony
    Dumeny, Leanne
    Hu, Qiongyao
    He, Yong
    O'Malley, Kerri
    Jiang, Zhihua
    Tran-Son-Tay, Roger
    Berceli, Scott
    ANNALS OF BIOMEDICAL ENGINEERING, 2017, 45 (03) : 644 - 655
  • [42] Vascular smooth muscle cells in intracranial aneurysms
    Wang, Zhenye
    Ma, Jia
    Yue, Hongyan
    Zhang, Zhewei
    Fang, Fei
    Wang, Guixue
    Liu, Xiaoheng
    Shen, Yang
    MICROVASCULAR RESEARCH, 2023, 149
  • [43] Hemodynamic Influence on Smooth Muscle Cell Kinetics and Phenotype During Early Vein Graft Adaptation
    Benjamin Klein
    Anthony Destephens
    Leanne Dumeny
    Qiongyao Hu
    Yong He
    Kerri O’Malley
    Zhihua Jiang
    Roger Tran-Son-Tay
    Scott Berceli
    Annals of Biomedical Engineering, 2017, 45 : 644 - 655
  • [44] Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype
    Wamhoff, Brian R.
    Lynch, Kevin R.
    Macdonald, Timothy L.
    Owens, Gary K.
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2008, 28 (08) : 1454 - 1461
  • [45] Mesoderm/Mesenchyme Homeobox Gene L Promotes Vascular Smooth Muscle Cell Phenotypic Modulation and Vascular Remodeling
    Wu, Bing
    Zhang, Lei
    Tang, Junming
    Chen, Shiyou
    Wang, Jianing
    CIRCULATION, 2017, 136
  • [46] Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity
    Frismantiene, Agne
    Philippova, Maria
    Erne, Paul
    Resink, Therese J.
    CELLULAR SIGNALLING, 2018, 52 : 48 - 64
  • [47] Mesoderm/mesenchyme homeobox gene 1 promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling
    Wu, Bing
    Zhang, Lei
    Zhu, Yun-He
    Zhang, You-en
    Zheng, Fei
    Yang, Jian-Ye
    Guo, Ling-Yun
    Li, Xing-Yuan
    Wang, Lu
    Tang, Jun-Ming
    Chen, Shi-You
    Wang, Jia-Ning
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2018, 251 : 82 - 89
  • [48] MicroRNA miR145 Regulates TGFBR2 Expression and Matrix Synthesis in Vascular Smooth Muscle Cells
    Zhao, Ning
    Koenig, Sara N.
    Trask, Aaron J.
    Lin, Cho-Hao
    Hans, Chetan P.
    Garg, Vidu
    Lilly, Brenda
    CIRCULATION RESEARCH, 2015, 116 (01) : 23 - U73
  • [49] MicroRNA-29b inhibits human vascular smooth muscle cell proliferation via targeting the TGF-β/Smad3 signaling pathway
    Li, Lirong
    Ren, Shaohua
    Hao, Xudong
    Zhen, Zigang
    Ji, Lei
    Ji, Hongming
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021, 21 (05)
  • [50] Lineage tracking of origin and fate of smooth muscle cells in atherosclerosis
    Bentzon, Jacob F.
    Majesky, Mark W.
    CARDIOVASCULAR RESEARCH, 2018, 114 (04) : 492 - 500
12345