MicroRNA and vascular smooth muscle cell phenotype: new therapy for atherosclerosis?

被引：27
|
作者：
Zhang, Chunxiang [1 ]
机构：
[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Anesthesiol, RNA & Cardiovasc Res Lab, Newark, NJ 07101 USA
来源：
GENOME MEDICINE | 2009年 / 1卷
基金：
美国国家卫生研究院;
关键词：
Phenotypic Modulation; Atherosclerotic Vascular Disease; VSMC Proliferation; Atherosclerotic Artery; Smooth Muscle Cell Phenotype;
D O I：
10.1186/gm85
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
MicroRNAs (miRNAs) represent a class of small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have identified that miR-145 is the most abundant miRNA in normal arteries and vascular smooth muscle cells (VSMCs), and its expression is significantly downregulated in dedifferentiated VSMCs and atherosclerotic arteries. miR-145 plays a critical role in modulating VSMC phenotype. Because phenotypic modulation of VSMCs is an initial cellular event in the development of atherosclerosis, miRNAs, and miR-145 in particular, may represent new therapeutic targets for atherosclerosis.
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页数：3
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