MicroRNA and vascular smooth muscle cell phenotype: new therapy for atherosclerosis?

被引：27

作者：

Zhang, Chunxiang ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, New Jersey Med Sch, Dept Anesthesiol, RNA & Cardiovasc Res Lab, Newark, NJ 07101 USA

来源：

GENOME MEDICINE | 2009年 / 1卷

基金：

美国国家卫生研究院;

关键词：

Phenotypic Modulation; Atherosclerotic Vascular Disease; VSMC Proliferation; Atherosclerotic Artery; Smooth Muscle Cell Phenotype;

D O I：

10.1186/gm85

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

MicroRNAs (miRNAs) represent a class of small, non-coding RNAs that negatively regulate gene expression via degradation or translational inhibition of their target mRNAs. Recent studies have identified that miR-145 is the most abundant miRNA in normal arteries and vascular smooth muscle cells (VSMCs), and its expression is significantly downregulated in dedifferentiated VSMCs and atherosclerotic arteries. miR-145 plays a critical role in modulating VSMC phenotype. Because phenotypic modulation of VSMCs is an initial cellular event in the development of atherosclerosis, miRNAs, and miR-145 in particular, may represent new therapeutic targets for atherosclerosis.

引用

页数：3

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