Successful Treatment of Macroglossia Due to Lymphatic Malformation With Sirolimus

被引：23

作者：

Yesil, Sule ^{[1
]}

Bozkurt, Ceyhun ^{[1
]}

Tanyildiz, Hikmet Gulsah ^{[1
]}

Tekgunduz, Sibel Akpinar ^{[1
]}

Candir, Mehmet Onur ^{[1
]}

Toprak, Sule ^{[1
]}

Sahin, Gurses ^{[1
]}

机构：

[1] Dr Sami Ulus Matern & Children Res & Training Hos, TR-06080 Ankara, Turkey

来源：

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | 2015年 / 124卷 / 10期

关键词：

lymphatic malformation; macroglossia; sirolimus; TONGUE; NECK; HEAD; LYMPHANGIOMAS; MANAGEMENT; RESECTION; CHILDREN;

D O I：

10.1177/0003489415583330

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Objective: To evaluate the effectiveness and safety of sirolimus therapy in a child with macroglossia due to lymphatic malformation. Methods: Sirolimus treatment was applied to the patient with an initial dosing of 0.8 mg/m(2) per dose, administered orally, twice daily at approximately 12-hour intervals. Results: After 9 months of sirolimus therapy, there was a nearly complete resolution of lymphatic malformation. The last evaluation was performed 6 months after withdrawal of treatment, and the lesion had almost completely resolved. Conclusion: This article presents a novel approach to the treatment of lymphatic malformation of the tongue using sirolimus, which appears to be safe and effective for the management of complex cases.

引用

页码：820 / 823

页数：4

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