Autophagy and IL-1 family cytokines

被引：73

作者：

Harris, James ^{[1
]}

机构：

[1] Monash Univ, Fac Med Nursing & Hlth Sci, Monash Med Ctr, Clayton, Vic, Australia

来源：

FRONTIERS IN IMMUNOLOGY | 2013年 / 4卷

关键词：

autophagosome; autophagy; cytokines; inflammasome; inflammation; interleukin; IL-1; IL-18;

D O I：

10.3389/fimmu.2013.00083

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autophagy is an important intracellular homeostatic mechanism for the targeting of cytosolic constituents, including organelles, for lysosomal degradation. Autophagy plays roles in numerous physiological processes, including immune cell responses to endogenous and exogenous pathogenic stimuli. Moreover, autophagy has a potentially pivotal role to play in the regulation of inflammatory responses. In particular, autophagy regulates endogenous inflammasome activators, as well as inflammasome components and pro-IL-1 beta. As a result, autophagy acts a key modulator of IL-1 beta and IL-18, as well as IL-1 alpha, release. This review focuses specifically on the role autophagy plays in regulating the production, processing, and secretion of IL-1 and IL-18 and the consequences of this important function.

引用

页数：6

共 60 条

[1] Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α [J].

Afonina, Inna S. ;

Tynan, Graham A. ;

Logue, Susan E. ;

Cullen, Sean P. ;

Bots, Michael ;

Luethi, Alexander U. ;

Reeves, Emer P. ;

McElvaney, Noel G. ;

Medema, Jan P. ;

Lavelle, Ed C. ;

Martin, Seamus J. .

MOLECULAR CELL, 2011, 44 (02) :265-278

[2]

AHLBERG J, 1982, LAB INVEST, V47, P523

[3] Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance [J].

Aichinger, Martin ;

Wu, Chunyan ;

Nedjic, Jelena ;

Klein, Ludger .

JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (02) :287-300

[4] Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients [J].

Brinar, Marko ;

Vermeire, Severine ;

Cleynen, Isabelle ;

Lemmens, Bart ;

Sagaert, Xavier ;

Henckaerts, Liesbet ;

Van Assche, Gert ;

Geboes, Karel ;

Rutgeerts, Paul ;

De Hertogh, Gert .

JOURNAL OF CROHNS & COLITIS, 2012, 6 (01) :43-50

[5] Autophagy protects against active tuberculosis by suppressing bacterial burden and inflammation [J].

Castillo, Eliseo F. ;

Dekonenko, Alexander ;

Arko-Mensah, John ;

Mandell, Michael A. ;

Dupont, Nicolas ;

Jiang, Shanya ;

Delgado-Vargas, Monica ;

Timmins, Graham S. ;

Bhattacharya, Dhruva ;

Yang, Hongliang ;

Hutt, Julie ;

Lyons, C. Rick ;

Dobos, Karen M. ;

Deretic, Vojo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (46) :E3168-E3176

[6] Autophagy in the immune response to tuberculosis: clinical perspectives [J].

Cheallaigh, C. Ni ;

Keane, J. ;

Lavelle, E. C. ;

Hope, J. C. ;

Harris, J. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2011, 164 (03) :291-300

[7] Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls [J].

Craddock, Nick ;

Hurles, Matthew E. ;

Cardin, Niall ;

Pearson, Richard D. ;

Plagnol, Vincent ;

Robson, Samuel ;

Vukcevic, Damjan ;

Barnes, Chris ;

Conrad, Donald F. ;

Giannoulatou, Eleni ;

Holmes, Chris ;

Marchini, Jonathan L. ;

Stirrups, Kathy ;

Tobin, Martin D. ;

Wain, Louise V. ;

Yau, Chris ;

Aerts, Jan ;

Ahmad, Tariq ;

Andrews, T. Daniel ;

Arbury, Hazel ;

Attwood, Anthony ;

Auton, Adam ;

Ball, Stephen G. ;

Balmforth, Anthony J. ;

Barrett, Jeffrey C. ;

Barroso, Ines ;

Barton, Anne ;

Bennett, Amanda J. ;

Bhaskar, Sanjeev ;

Blaszczyk, Katarzyna ;

Bowes, John ;

Brand, Oliver J. ;

Braund, Peter S. ;

Bredin, Francesca ;

Breen, Gerome ;

Brown, Morris J. ;

Bruce, Ian N. ;

Bull, Jaswinder ;

Burren, Oliver S. ;

Burton, John ;

Byrnes, Jake ;

Caesar, Sian ;

Clee, Chris M. ;

Coffey, Alison J. ;

Connell, John M. C. ;

Cooper, Jason D. ;

Dominiczak, Anna F. ;

Downes, Kate ;

Drummond, Hazel E. ;

Dudakia, Darshna .

NATURE, 2010, 464 (7289) :713-U86

[8] Autophagy is required for the activation of NFκB [J].

Criollo, Alfredo ;

Chereau, Fanny ;

Malik, Shoaib Ahmad ;

Niso-Santano, Mireia ;

Marino, Guillermo ;

Galluzzi, Lorenzo ;

Maiuri, Maria Chiara ;

Baud, Veronique ;

Kroemer, Guido .

CELL CYCLE, 2012, 11 (01) :194-199

[9] Inflammasome-Independent Modulation of Cytokine Response by Autophagy in Human Cells [J].

Crisan, Tania O. ;

Plantinga, Theo S. ;

de Veerdonk, Frank L. van ;

Farcas, Marius F. ;

Stoffels, Monique ;

Kullberg, Bart-Jan ;

van der Meer, Jos W. M. ;

Joosten, Leo A. B. ;

Netea, Mihai G. .

PLOS ONE, 2011, 6 (04)

[10] The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases [J].

Davis, Beckley K. ;

Wen, Haitao ;

Ting, Jenny P. -Y. .

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :707-735

← 1 2 3 4 5 6 →