Plasma IP-10 Is Associated with Rapid Disease Progression in Early HIV-1 Infection

被引：79

作者：

Jiao, Yanmei ^{[1
]}

Zhang, Tong ^{[1
]}

Wang, Rui ^{[1
]}

Zhang, Hongwei ^{[1
]}

Huang, Xiaojie ^{[1
]}

Yin, Jiming ^{[2
]}

Zhang, Liguo ^{[3
]}

Xu, Xiaoning ^{[1
]}

Wu, Hao ^{[1
]}

机构：

[1] Capital Med Univ, Beijing You An Hosp, Ctr Infect Dis, Beijing 100069, Peoples R China

[2] Capital Med Univ, Beijing You An Hosp, Beijing Inst Liver Dis, Beijing 100069, Peoples R China

[3] Chinese Acad Sci, Inst Biophys, Beijing 100080, Peoples R China

来源：

VIRAL IMMUNOLOGY | 2012年 / 25卷 / 04期

关键词：

IMMUNE ACTIVATION; C-VIRUS; RESPONSES; VIREMIA; CELLS; AIDS;

D O I：

10.1089/vim.2012.0011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines play key roles in modulating disease progression in simian immunodeficiency virus/human immunodeficiency virus (SIV/HIV) infection. There are a few studies on the relationship between early cytokines and HIV disease prognosis. In this study, we first report the relationship based on two groups with clearly different disease progression. We found that IP-10 was the only cytokine among the 26 cytokines tested that was always positively correlated with disease progression, and was associated with the time for CD4 counts to fall below 200 cells/mu L during Fiebig stages III-V in HIV-1 infection. This suggests that high IP-10 levels in the blood are associated with rapid disease progression during Fiebig stages III-V in HIV-1 infection.

引用

页码：333 / 337

页数：5

共 16 条

[1] Innate immune responses in primary HIV-1 infection [J].

Borrow, Persephone ;

Bhardwaj, Nina .

CURRENT OPINION IN HIV AND AIDS, 2008, 3 (01) :36-44

[2] Immune activation set point during early FHV infection predicts subsequent CD4+ T-cell changes independent of viral load [J].

Deeks, SG ;

Kitchen, CMR ;

Liu, L ;

Guo, H ;

Gascon, R ;

Narváez, AB ;

Hunt, P ;

Martin, JN ;

Kahn, JO ;

Levy, J ;

McGrath, MS ;

Hecht, FM .

BLOOD, 2004, 104 (04) :942-947

[3] Elevated Levels of Innate Immune Modulators in Lymph Nodes and Blood Are Associated with More-Rapid Disease Progression in Simian Immunodeficiency Virus-Infected Monkeys [J].

Durudas, Andre ;

Milush, Jeffrey M. ;

Chen, Hui-Ling ;

Engram, Jessica C. ;

Silvestri, Guido ;

Sodora, Donald L. .

JOURNAL OF VIROLOGY, 2009, 83 (23) :12229-12240

[4] Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection [J].

Fiebig, EW ;

Wright, DJ ;

Rawal, BD ;

Garrett, PE ;

Schumacher, RT ;

Peddada, L ;

Heldebrant, C ;

Smith, R ;

Conrad, A ;

Kleinman, SH ;

Busch, MP .

AIDS, 2003, 17 (13) :1871-1879

[5] Persistent immune activation in HIV-1 infection is associated with progression to AIDS [J].

Hazenberg, MD ;

Otto, SA ;

van Benthem, BHB ;

Roos, MTL ;

Coutinho, RA ;

Lange, JMA ;

Hamann, D ;

Prins, M ;

Miedema, F .

AIDS, 2003, 17 (13) :1881-1888

[6] Analysis of the immune responses in chimpanzees infected with HIV type 1 isolates [J].

Juompan, Laure Y. ;

Hutchinson, Karen ;

Montefiori, David C. ;

Nidtha, Soumya ;

Villinger, Francois ;

Novembre, Francis J. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2008, 24 (04) :573-586

[7] Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS [J].

Kornfeld, C ;

Ploquin, MJY ;

Pandrea, I ;

Faye, A ;

Onanga, R ;

Apetrei, C ;

Poaty-Mavoungou, V ;

Rouquet, P ;

Estaquier, J ;

Mortara, L ;

Desoutter, JF ;

Butor, C ;

Le Grand, R ;

Roques, P ;

Simon, F ;

Barré-Sinoussi, F ;

Diop, OM ;

Müller-Trutwin, MC .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (04) :1082-1091

[8] The C-X-C chemokine IP-10 stimulates HIV-1 replication [J].

Lane, BR ;

King, SR ;

Bock, PJ ;

Strieter, RM ;

Coffey, MJ ;

Markovitz, DM .

VIROLOGY, 2003, 307 (01) :122-134

[9] CXCL10/IP-10 in infectious diseases pathogenesis and potential therapeutic implications [J].

Liu, Mingli ;

Guo, Shanchun ;

Hibbert, Jacqueline M. ;

Jain, Vidhan ;

Singh, Neeru ;

Wilson, Nana O. ;

Stiles, Jonathan K. .

CYTOKINE & GROWTH FACTOR REVIEWS, 2011, 22 (03) :121-130

[10] Resolution of immune activation defines nonpathogenic SIV infection [J].

Manches, Olivier ;

Bhardwaj, Nina .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (12) :3512-3515

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