Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells

被引：106

作者：

Celia, Christian ^{[1
,2
]}

Trapasso, Elena ^{[3
]}

Locatelli, Marcello ^{[1
]}

Navarra, Michele ^{[4
]}

Ventura, Cinzia Anna ^{[4
]}

Wolfram, Joy ^{[2
,5
]}

Carafa, Maria ^{[6
]}

Morittu, Valeria Maria ^{[3
]}

Britti, Domenico ^{[3
]}

Di Marzio, Luisa ^{[1
]}

Paolino, Donatella ^{[3
]}

机构：

[1] Univ G dAnnunzio, Dept Pharm, I-66013 Chieti, Italy

[2] Methodist Hosp, Res Inst, Dept Nanomed, Houston, TX 77030 USA

[3] Magna Graecia Univ Catanzaro, Dept Hlth Sci, I-88100 Catanzaro, Italy

[4] Univ Messina, Dept Drug Sci & Hlth Prod, I-98168 Messina, Italy

[5] Natl Ctr Nanosci & Technol China, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China

[6] Univ Roma La Sapienza, Dept Drug Chem & Technol, I-00185 Rome, Italy

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 112卷

关键词：

Natural products; Liposomes; Bergamot essential oil (BEO); Citrus extracts; Cancer; SH-SY5Y human neuroblastoma cells; OF-THE-ART; IN-VITRO; ANTIINFLAMMATORY ACTIVITY; PHARMACOKINETIC FEATURES; INHIBITS PROLIFERATION; POTENTIAL TREATMENT; CITRUS LIMONOIDS; GEMCITABINE; DELIVERY; APOPTOSIS;

D O I：

10.1016/j.colsurfb.2013.09.017

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Citrus extracts, particularly bergamot essential oil (BEO) and its fractions, have been found to exhibit anticancer efficacy. However, the poor water solubility, low stability and limited bioavailability have prevented the use of BEO in cancer therapy. To overcome such drawbacks, we formulated BEO liposomes that improved the water solubility of the phytocomponents and increased their anticancer activity in vitro against human SH-SY5Y neuroblastoma cells. The results warrant further investigation of BEO liposomes for in vivo applications. (C) 2013 Published by Elsevier B.V.

引用

页码：548 / 553

页数：6

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