Absence of Post-Transplantation Lymphoproliferative Disorder after Allogeneic Blood or Marrow Transplantation Using Post-Transplantation Cyclophosphamide as Graft-versus-Host Disease Prophylaxis

被引：88

作者：

Kanakry, Jennifer A. ^{[1
]}

Kasamon, Yvette L. ^{[2
]}

Bolanos-Meade, Javier ^{[2
]}

Borrello, Ivan M. ^{[2
]}

Brodsky, Robert A. ^{[1
]}

Fuchs, Ephraim J. ^{[2
]}

Ghosh, Nilanjan ^{[2
]}

Gladstone, Douglas E. ^{[2
]}

Gocke, Christopher D. ^{[3
]}

Huff, Carol Ann ^{[2
]}

Kanakry, Christopher G. ^{[2
]}

Luznik, Leo ^{[2
]}

Matsui, William ^{[2
]}

Mogri, Huzefa J. ^{[4
]}

Swinnen, Lode J. ^{[2
]}

Symons, Heather J. ^{[5
]}

Jones, Richard J. ^{[2
]}

Anibinder, Richard E. ^{[2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Hematol, Baltimore, MD 21287 USA

[2] Johns Hopkins Univ, Dept Hematol Malignancies, Sch Med, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Dept Pathol, Sch Med, Baltimore, MD 21287 USA

[4] Johns Hopkins Univ, Dept Med, Sch Med, Baltimore, MD 21287 USA

[5] Johns Hopkins Univ, Dept Pediat Oncol, Sch Med, Baltimore, MD 21287 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2013年 / 19卷 / 10期

关键词：

Post-transplantation lymphoproliferative disorder; Allogeneic blood or marrow transplantation; Post-transplantation cyclophosphamide; Graft-versus-host disease prophylaxis; HIGH-DOSE CYCLOPHOSPHAMIDE; BARR-VIRUS REACTIVATION; HEMATOLOGIC MALIGNANCIES; PREEMPTIVE RITUXIMAB; EBV REACTIVATION; RISK; DEPLETION; THERAPY; CELLS;

D O I：

10.1016/j.bbmt.2013.07.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immunosuppressive regimens that effectively prevent graft-versus-host disease (GVHD) after allogeneic blood or marrow transplantation (allo-BMT) have been associated with an increased incidence of post-transplantation lymphoproliferative disorder (PTLD) in the first year after transplantation. We evaluated the incidence of PTLD associated with the use of high-dose post-transplantation cyclophosphamide (PTCy) as GVHD prophylaxis. Between 2000 and 2011, a total of 785 adult allo-BMT recipients were given PTCy as GVHD prophylaxis at the Johns Hopkins Hospital, including 313 patients who received PTCy as sole GVHD prophylaxis. HLA-haploidentical or unrelated donor graft transplantation was performed in 526 patients (67%). No cases of PTLD occurred during the first year after allo-BMT in this series. PTLD is a rare occurrence after allo-BMT using PTCy, even in high-risk alternative donor transplantations. (C) 2013 American Society for Blood and Marrow Transplantation.

引用

页码：1514 / 1517

页数：4

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