Long-term efficacy of psoriasis vulgaris treatments: Analysis of treatment with topical corticosteroid and/or vitamin D3 analog, oral cyclosporin, etretinate and phototherapy over a 35-year period, 1975-2010

被引：2

作者：

Akasaka, Emiko ^{[1
]}

Mabuchi, Tomotaka ^{[1
]}

Manabe, Yasuaki ^{[1
]}

Yahagi, Eiichiro ^{[1
]}

Yamada-Hiruma, Azusa ^{[1
]}

Yamaoka, Hanako ^{[1
]}

Kojima, Tomoko ^{[1
]}

Kato, Masayuki ^{[1
]}

Ikoma, Norihiro ^{[1
]}

Ozawa, Akira ^{[1
]}

Haruki, Yasuo ^{[2
]}

机构：

[1] Tokai Univ, Sch Med, Dept Dermatol, Isehara, Kanagawa 2591193, Japan

[2] Tokai Univ, Sch Med, Dept Basic Med Sci, Isehara, Kanagawa 2591193, Japan

来源：

JOURNAL OF DERMATOLOGY | 2013年 / 40卷 / 04期

关键词：

background characteristics; classification of changes in severity; long-term efficacy; psoriasis vulgaris; treatment;

D O I：

10.1111/1346-8138.12069

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Various therapies have been tried for psoriasis. In Japan, biologics began to be used for psoriasis treatment in January 2010. Their clinical efficacy is well known, but biologics cannot be used in all psoriasis patients for reasons such as side-effects and cost. It is necessary to evaluate the effect of long-term psoriasis treatment, but there have been no reports evaluating long-term treatment. Therefore, the outcomes of patients who had been treated at the Tokai University Hospital for more than 5years, before biological agents were released, were examined. Three categories, classified by initial severity, changes in severity by method of treatment and background characteristics, were investigated. In conclusion, cases of long-term treatment with a combination of topical corticosteroid and topical vitamin D3 analog or oral cyclosporin were found to be effective therapies. Patients with a history of diabetes mellitus or cardiovascular disease of psoriasis were likely to be treatment resistant.

引用

页码：238 / 243

页数：6