Update Breast Cancer 2022 Part 3-Early-Stage Breast Cancer

被引：1

作者：

Fehm, Tanja N. ^{[1
]}

Welslau, Manfred ^{[2
]}

Mueller, Volkmar ^{[3
]}

Lueftner, Diana ^{[4
,5
]}

Schuetz, Florian ^{[6
]}

Fasching, Peter A. ^{[7
]}

Janni, Wolfgang ^{[8
]}

Thomssen, Christoph ^{[9
]}

Witzel, Isabell ^{[3
]}

Belleville, Erik ^{[10
]}

Untch, Michael ^{[11
]}

Thill, Marc ^{[12
]}

Tesch, Hans ^{[13
]}

Ditsch, Nina ^{[14
]}

Lux, Michael P. ^{[15
]}

Aktas, Bahriye ^{[16
]}

Banys-Paluchowski, Maggie ^{[17
]}

Schneeweiss, Andreas ^{[18
,19
]}

Kolberg-Liedtke, Cornelia ^{[20
]}

Hartkopf, Andreas D. ^{[8
]}

Woeckel, Achim ^{[21
]}

Kolberg, Hans-Christian ^{[22
]}

Harbeck, Nadia ^{[23
,24
]}

Stickeler, Elmar ^{[25
]}

机构：

[1] Univ Hosp Dusseldorf, Dept Gynecol & Obstet, Dusseldorf, Germany

[2] Onkol Aschaffenburg, Aschaffenburg, Germany

[3] Hamburg Eppendorf Univ Med Ctr, Dept Gynecol, Hamburg, Germany

[4] Immanuel Hosp Mark Schweiz, Buckow, Germany

[5] Med Univ Brandenburg TheodorFontane, Buckow, Germany

[6] Diakonissen Stiftungs Krankenhaus Speyer, Gynakol & Geburtshilfe, Speyer, Germany

[7] Friedrich Alexander Univ Erlangen Nuremberg, Erlangen Univ Hosp, Dept Gynecol & Obstet, Comprehens Canc Ctr Erlangen EMN, Erlangen, Germany

[8] Ulm Univ Hosp, Dept Gynecol & Obstet, Ulm, Germany

[9] Martin Luther Univ Halle Wittenberg, Halle, Saale, Germany

[10] ClinSol GmbH & Co KG, Wurzburg, Germany

[11] Helios Klinikum Berlin Buch, Gynecol Oncol Ctr, Breast Canc Ctr, Clin Gynecol & Obstet, Berlin, Germany

[12] Agaples Markus Krankenhaus, Dept Gynecol & Gynecol Oncol, Frankfurt, Germany

[13] Bethanien Hosp, Frankfurt, Germany

[14] Univ Hosp Augsburg, Dept Gynecol & Obstet, Augsburg, Germany

[15] St Vincenz Krankenhaus GmbH, Klin Gynakol & Geburtshilfe, Frauenklin St Louise Paderborn, St Josefs Krankenhaus, Salzkotten, Germany

[16] Univ Leipzig, Med Ctr, Dept Gynecol, Leipzig, Germany

[17] Univ Hosp Schleswig Holstein, Dept Gynecol & Obstet, Campus Lubeck, Lubeck, Germany

[18] Heidelberg Univ Hosp, Natl Ctr Tumor Dis NCT, Heidelberg, Germany

[19] German Canc Res Ctr, Heidelberg, Germany

[20] Univ Hosp Essen, Dept Gynecol & Obstet, Essen, Germany

[21] Univ Hosp Wurzburg, Wurzburg, Germany

[22] Marienhosp Bottrop, Dept Gynecol & Obstet, Bottrop, Germany

[23] LMU Univ Hosp, CCC Munich LMU, Munich, Germany

[24] LMU Univ Hosp, Dept Gynecol & Obstet, Breast Ctr, Munich, Germany

[25] RWTH Univ Hosp Aachen, Dept Gynecol & Obstet, Aachen, Germany

来源：

GEBURTSHILFE UND FRAUENHEILKUNDE | 2022年 / 82卷 / 09期

关键词：

breast cancer; early stage; adjuvant treatment; neoadjuvant treatment; chemotherapy; endocrine therapy; PROLIFERATION MARKER KI-67; PHASE-III; OPEN-LABEL; NEOADJUVANT PERTUZUMAB; MAMMOGRAPHIC DENSITY; POSTMENOPAUSAL WOMEN; SUSCEPTIBILITY LOCI; OVARIAN SUPPRESSION; TREATMENT DECISIONS; 70-GENE SIGNATURE;

D O I：

10.1055/a-1912-7105

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

This review summarizes recent developments in the prevention and treatment of patients with early-stage breast cancer. The individual disease risk for different molecular subtypes was investigated in a large epidemiological study. With regard to treatment, new data are available from long-term followup of the Aphinity study, as well as new data on neoadjuvant therapy with atezolizumab in HER2-positive patients. Bio-markers, such as residual cancer burden, were investigated in the context of pembrolizumab therapy. A Genomic Grade Index study in elderly patients is one of a group of studies investigating the use of modern multigene tests to identify patients with an excellent prognosis in whom chemotherapy may be avoided. These and other aspects of the latest developments in the diagnosis and treatment of breast cancer are described in this review.

引用

页码：912 / 921

页数：10

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