G-protein β3 subunit C825T polymorphism:: no association with risk for hypertension and obesity

Objective Several recent studies have indicated that a C825T polymorphism in the gene encoding the G-protein beta (3) subunit is a significant risk factor for hypertension and obesity. In this study, we tested whether this polymorphism is associated with hypertension and obesity in white men. Design Population-based prospective cohort study. Methods We followed a cohort of 903 men, aged 42-61 years at baseline, for an average time of 4.2 years. Genotyping was performed by polymerase chain reaction. Results The genotype distribution was in Hardy-Weinberg equilibrium: 514 (57%) had the CC genotype, 49 (5%) had the TT genotype and 340 (38%) were heterozygous (T:C = 0.24:0.76). There was no statistically significant difference between the genotype groups in respect to baseline and end of follow-up risk for hypertension or obesity, systolic or diastolic blood pressure, or body mass index. Conclusion We conclude that the C825T polymorphism of the G-protein beta (3) subunit gene does not notably contribute to the development of hypertension or obesity, and is not a significant determinant for blood pressure and body mass index in white men. J Hypertens 19:2149-2155 (C) 2001 Lippincott Williams & Wilkins.