SIRT1 Activators: The Evidence STACks up

被引:7
作者
Kugel, Sita [1 ]
Mostoslavsky, Raul [1 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
来源
AGING-US | 2013年 / 5卷 / 03期
关键词
SMALL-MOLECULE ACTIVATORS; RESVERATROL; SIRTUINS; SURVIVAL; SRT1720; BIOLOGY; MICE;
D O I
10.18632/aging.100534
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
引用
收藏
页码:142 / 143
页数:2
相关论文
共 10 条
[1]  
Baur JA, NATURE, V444, P337
[2]   Mechanism of human SIRT1 activation by resveratrol [J].
Borra, MT ;
Smith, BC ;
Denu, JM .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (17) :17187-17195
[3]   Recent progress in the biology and physiology of sirtuins [J].
Finkel, Toren ;
Deng, Chu-Xia ;
Mostoslavsky, Raul .
NATURE, 2009, 460 (7255) :587-591
[4]   Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan [J].
Howitz, KT ;
Bitterman, KJ ;
Cohen, HY ;
Lamming, DW ;
Lavu, S ;
Wood, JG ;
Zipkin, RE ;
Chung, P ;
Kisielewski, A ;
Zhang, LL ;
Scherer, B ;
Sinclair, DA .
NATURE, 2003, 425 (6954) :191-196
[5]   Substrate-specific activation of sirtuins by resveratrol [J].
Kaeberlein, M ;
McDonagh, T ;
Heltweg, B ;
Hixon, J ;
Westman, EA ;
Caldwell, SD ;
Napper, A ;
Curtis, R ;
DiStefano, PS ;
Fields, S ;
Bedalov, A ;
Kennedy, BK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (17) :17038-17045
[6]   Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes [J].
Milne, Jill C. ;
Lambert, Philip D. ;
Schenk, Simon ;
Carney, David P. ;
Smith, Jesse J. ;
Gagne, David J. ;
Jin, Lei ;
Boss, Olivier ;
Perni, Robert B. ;
Vu, Chi B. ;
Bemis, Jean E. ;
Xie, Roger ;
Disch, Jeremy S. ;
Ng, Pui Yee ;
Nunes, Joseph J. ;
Lynch, Amy V. ;
Yang, Hongying ;
Galonek, Heidi ;
Israelian, Kristine ;
Choy, Wendy ;
Iffland, Andre ;
Lavu, Siva ;
Medvedik, Oliver ;
Sinclair, David A. ;
Olefsky, Jerrold M. ;
Jirousek, Michael R. ;
Elliott, Peter J. ;
Westphal, Christoph H. .
NATURE, 2007, 450 (7170) :712-716
[7]   SRT1720 improves survival and healthspan of obese mice [J].
Minor, Robin K. ;
Baur, Joseph A. ;
Gomes, Ana P. ;
Ward, Theresa M. ;
Csiszar, Anna ;
Mercken, Evi M. ;
Abdelmohsen, Kotb ;
Shin, Yu-Kyong ;
Canto, Carles ;
Scheibye-Knudsen, Morten ;
Krawczyk, Melissa ;
Irusta, Pablo M. ;
Martin-Montalvo, Alejandro ;
Hubbard, Basil P. ;
Zhang, Yongqing ;
Lehrmann, Elin ;
White, Alexa A. ;
Price, Nathan L. ;
Swindell, William R. ;
Pearson, Kevin J. ;
Becker, Kevin G. ;
Bohr, Vilhelm A. ;
Gorospe, Myriam ;
Egan, Josephine M. ;
Talan, Mark I. ;
Auwerx, Johan ;
Westphal, Christoph H. ;
Ellis, James L. ;
Ungvari, Zoltan ;
Vlasuk, George P. ;
Elliott, Peter J. ;
Sinclair, David A. ;
de Cabo, Rafael .
SCIENTIFIC REPORTS, 2011, 1
[8]   SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents [J].
Nayagam, Vasantha M. ;
Wang, Xukun ;
Tan, Yong Cheng ;
Poulsen, Anders ;
Goh, Kee Chuan ;
Ng, Tony ;
Wang, Haishan ;
Song, Hong Yan ;
Ni, Binhui ;
Entzeroth, Michael ;
Stunkel, Walter .
JOURNAL OF BIOMOLECULAR SCREENING, 2006, 11 (08) :959-967
[9]   SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1 [J].
Pacholec, Michelle ;
Bleasdale, John E. ;
Chrunyk, Boris ;
Cunningham, David ;
Flynn, Declan ;
Garofalo, Robert S. ;
Griffith, David ;
Griffor, Matt ;
Loulakis, Pat ;
Pabst, Brandon ;
Qiu, Xiayang ;
Stockman, Brian ;
Thanabal, Venkataraman ;
Varghese, Alison ;
Ward, Jessica ;
Withka, Jane ;
Ahn, Kay .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (11) :8340-8351
[10]   From Sirtuin Biology to Human Diseases: An Update [J].
Sebastian, Carlos ;
Satterstrom, F. Kyle ;
Haigis, Marcia C. ;
Mostoslavsky, Raul .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (51) :42444-42452