Lead-interacting proteins and their implication in lead poisoning

被引：87

作者：

de Souza, Iara Dantas ^{[1
]}

de Andrade, Abraao Silveira ^{[1
]}

Siqueira Dalmolin, Rodrigo Juliani ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Norte, Bioinformat Multidisciplinary Environm IMD, Natal, RN, Brazil

[2] Univ Fed Rio Grande do Norte, Dept Biochem CB, Natal, RN, Brazil

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 2018年 / 48卷 / 05期

关键词：

heavy metals; lead intoxication; environmental toxicity; systems toxicology; environmental health; systemic effect of lead poisoning; PYRIMIDINE 5'-NUCLEOTIDASE DEFICIENCY; TRANSCRIPTION FACTOR-IIIA; CALCIUM-BINDING PROTEINS; INCLUSION-BODY FORMATION; BLOOD-BRAIN-BARRIER; RAT-BRAIN; KINASE-C; DNA-BINDING; MOLECULAR-MECHANISMS; SYNAPTIC PLASTICITY;

D O I：

10.1080/10408444.2018.1429387

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Lead is an important heavy metal used worldwide in several applications, especially in industry. People exposed to lead can develop a wide range of symptoms associated with lead poisoning. Many effects of lead poisoning are reported in the literature, showing a compromising of whole body health, with symptoms related to cardiovascular, immune, bone, reproductive, hematological, renal, gastrointestinal, and nervous system. However, the molecular lead targets as well as the pathways affected by lead poisoning are not completely described. The aim of this study was to construct a map of metabolic pathways impaired in lead poisoning by evaluating which biomolecules are directly affected by lead. Through manual literature curation, we identified proteins which physically interact with lead and subsequently determined the metabolic pathways those proteins are involved with. At total, we identified 23 proteins involved with heme synthesis, calcium metabolism, neurotransmission, among other biological systems, which helps to understand the wide range of lead-poisoning symptoms.

引用

页码：375 / 386

页数：12

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