Regulation of transcription of MHC class II genes

被引：175
作者：
Boss, JM
机构：
[1] Dept. of Microbiology and Immunology, Emory Univ. Sch. Med., 3131 R., Atlanta
来源：
CURRENT OPINION IN IMMUNOLOGY | 1997年 / 9卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0952-7915(97)80166-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Genetic and biochemical analyses have identified multiple DNA-binding and non-DNA-binding proteins that functionally regulate MHC class II genes. These include RFX, X2BP, NF-Y, CIITA, OCT-2 and Bob1. One of the essential non-DNA-binding proteins, CIITA, appears to function as a limiting molecular switch that is responsible for the control of class II expression and the regulation of expression by interferon-gamma.
引用
收藏
页码：107 / 113
页数：7
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