One-pot synthesis of substituted pyrrole-imidazole derivatives with anticancer activity

被引：21

作者：

Zhang, Ming ^{[1
,2
,3
]}

Ding, Yong ^{[4
]}

Qin, Hong-Xia ^{[4
]}

Xu, Zhi-Gang ^{[4
]}

Lan, Hai-Tao ^{[2
,3
]}

Yang, Dong-Lin ^{[4
]}

Yi, Cheng ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Abdominal Canc, West China Clin Med Sch, 37 Guoxue Xiang, Chengdu 610041, Peoples R China

[2] Univ Elect Sci & Technol China, Acad Med Sci, Canc Ctr, Chengdu 610000, Sichuan, Peoples R China

[3] Univ Elect Sci & Technol China, Affiliated Hosp, Sichuan Prov Peoples Hosp, Chengdu 610000, Sichuan, Peoples R China

[4] Chongqing Univ Arts & Sci, Int Acad Targeted Therapeut & Innovat, 319 Honghe Ave, Chongqing 402160, Peoples R China

来源：

MOLECULAR DIVERSITY | 2020年 / 24卷 / 04期

关键词：

Pyrrole-imidazole; MCRs; Microwave irradiation; One pot; Anticancer activity; RELATIVE CONFIGURATION; INDOLE; CYCLIZATION;

D O I：

10.1007/s11030-019-09982-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A facile and efficient method to synthesize pyrrole-imidazole was developed via a post-Ugi cascade reaction followed by one purification procedure. Synthesized pyrrole-imidazole was collected by performing a mild reaction and a simple procedure, which could be applicable to a broad scope of functionalized anilines. The screening results demonstrated that compound 7e exhibited a high potency of anticancer activity in human pancreatic cancer cell lines PANC and ASPC-1. Our work shed light on the potential of post-Ugi cascade reaction in combinatorial and medicinal chemistry.

引用

页码：1177 / 1184

页数：8

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