Relevance of glutamate levels in the CSF of patients with HIV-1-associated dementia complex

被引：16
|
作者：
Espey, MG
Ellis, RJ
Heaton, RK
Basile, AS
机构：
[1] NIDDKD, Bioorgan Chem Lab, NIH, Bethesda, MD 20892 USA
[2] Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA
[3] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
[4] HIV Neurobeh Res Ctr, San Diego, CA USA
来源：
NEUROLOGY | 1999年 / 53卷 / 05期
关键词：
CSF; HIV; HIV-1 associated dementia complex;
D O I：
10.1212/WNL.53.5.1144
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Chronic hyperactivation of excitatory amino acid pathways in the CNS of patients infected with HIV-1 may contribute to the pathogenesis of HIV-l-associated dementia complex. However, no correlation between the concentration of glutamate in CSF (mean 3.3 mu mol/L) and either HIV-1 infection or HTV-1-associated dementia complex was observed. The results clarify several important issues regarding analysis of glutamate in the CSF and the role of excitotoxins in HIV-1-associated dementia complex.
引用
收藏
页码：1144 / 1145
页数：2
相关论文
共 50 条
  • [1] Role for astrocytosis in HIV-1-associated dementia
    Vitkovic, L
    daCunha, A
    HIV AND DEMENTIA, 1995, 202 : 105 - 116
  • [2] The regulation of alpha chemokines during HIV-1 infection and leukocyte activation: relevance for HIV-1-associated dementia
    Poluektova, L
    Moran, T
    Zelivyanskaya, M
    Swindells, S
    Gendelman, HE
    Persidsky, Y
    JOURNAL OF NEUROIMMUNOLOGY, 2001, 120 (1-2) : 112 - 128
  • [3] Increased glutamate in CSF and plasma of patients with HIV dementia
    Ferrarese, C
    Aliprandi, A
    Tremolizzo, L
    Stanzani, L
    De Micheli, A
    Dolara, A
    Frattola, L
    NEUROLOGY, 2001, 57 (04) : 671 - 675
  • [4] Potentiation of excitotoxicity in HIV-1-associated Dementia and the significance of glutaminase
    Erdmann, Nathan B.
    Whitney, Nicholas P.
    Zheng, Jialin
    CLINICAL NEUROSCIENCE RESEARCH, 2006, 6 (05) : 315 - 328
  • [5] NEUROBEHAVIORAL AND NEUROIMAGING CORRELATIONS IN HIV-1-ASSOCIATED DEMENTIA COMPILER
    ORTEGO, JN
    CHANG, L
    MILLER, BL
    OROPILLA, G
    MEYER, H
    SATZ, P
    MENA, I
    NEUROLOGY, 1994, 44 (04) : A248 - A248
  • [6] Increased glutamate in CSF and plasma of patients with HIV dementia - Reply
    Aliprandi, A
    Longoni, M
    Tremolizzo, L
    Ferrarese, C
    NEUROLOGY, 2002, 58 (09) : 1439 - 1440
  • [7] HIV-1 and the brain: connections between HIV-1-associated dementia, neuropathology and neuroimmunology
    Lawrence, DM
    Major, EO
    MICROBES AND INFECTION, 2002, 4 (03) : 301 - 308
  • [8] LABORATORY EVALUATIONS IN HIV-1-ASSOCIATED COGNITIVE MOTOR COMPLEX
    SYNDULKO, K
    SINGER, EJ
    NOGALESGAETE, J
    CONRAD, A
    SCHMID, P
    TOURTELLOTTE, WW
    PSYCHIATRIC CLINICS OF NORTH AMERICA, 1994, 17 (01) : 91 - 123
  • [9] A proteomic fingerprint of cerebrospinal fluids from individuals with HIV-1-associated dementia
    Rozek, W.
    Holloway, S.
    Ricardo-Dukelow, M.
    Ciborowski, P.
    MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (10) : S73 - S73
  • [10] HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia
    Xiong, HG
    Zeng, YC
    Lewis, T
    Zheng, JL
    Persidsky, Y
    Gendelman, HE
    JOURNAL OF NEUROVIROLOGY, 2000, 6 : S14 - S23
12345