Single Continuous Wave Laser Induced Photodynamic/Plasmonic Photothermal Therapy Using Photosensitizer-Functionalized Gold Nanostars

被引：463

作者：

Wang, Shouju ^{[1
,2
]}

Huang, Peng ^{[2
,3
]}

Nie, Liming ^{[2
,4
]}

Xing, Ruijun ^{[2
]}

Liu, Dingbin ^{[2
]}

Wang, Zhe ^{[2
,4
]}

Lin, Jing ^{[2
,3
]}

Chen, Shouhui ^{[2
]}

Niu, Gang ^{[2
]}

Lu, Guangming ^{[1
]}

Chen, Xiaoyuan ^{[2
]}

机构：

[1] Nanjing Univ, Dept Med Imaging, Jinling Hosp, Sch Clin,Med Coll, Nanjing 210000, Jiangsu, Peoples R China

[2] NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA

[3] Shanghai Jiao Tong Univ, Inst Micronano Sci & Technol, Shanghai 200240, Peoples R China

[4] Xiamen Univ, Sch Publ Hlth, Ctr Mol Imaging & Translat Med, Xiamen 361005, Peoples R China

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 22期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

gold nanostars; chlorin e6; continuous wave lasers; photodynamic therapy; plasmonic photothermal therapy; GRAPHENE OXIDE; CANCER; NANOCRYSTALS; DESTRUCTION; NANORODS;

D O I：

10.1002/adma.201204623

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3055 / 3061

页数：7

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