Intermolecular Aminotrifluoromethylation of Alkenes by Visible-Light-Driven Photoredox Catalysis

被引：285
作者：
Yasu, Yusuke [1 ]
Koike, Takashi [1 ]
Akita, Munetaka [1 ]
机构：
[1] Tokyo Inst Technol, Chem Resources Lab, Midori Ku, Yokohama, Kanagawa 2268503, Japan
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 09期
关键词：
ELECTROPHILIC TRIFLUOROMETHYLATION; ORGANIC-SYNTHESIS; OXYTRIFLUOROMETHYLATION; HYDROTRIFLUOROMETHYLATION; DIFUNCTIONALIZATION; PHOTOCHEMISTRY; PHOTOCATALYSIS; PHOTOPHYSICS; HETEROCYCLES; ALDEHYDES;
D O I：
10.1021/ol4006272
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Intermolecular aminotrifluoromethylation of alkenes catalyzed by [Ru(bpy)(3)](2+) under visible light irradiation has been explored. The present photocatalytic protocol achieves highly efficient and regioselective difunctionalization of C=C bonds, leading to a variety of beta-trifluoromethylamines. The reaction is applied to "late-stage aminotrifluoromethylation" of steroid and amino acid scaffolds.
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收藏
页码：2136 / 2139
页数：4
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