Isolation and synthesis of the first natural 6-hydroximino 4-en-3-one- steroids from the sponges Cinachyrella spp.

被引：61

作者：

Rodriguez, J

Nunez, L

Peixinho, S

Jimenez, C

机构：

[1] UNIV A CORUNA, FAC CIENCIAS, DEPT QUIM FUNDAMENTAL & IND, LA CORUNA 15071, SPAIN

[2] UNIV FED BAHIA, INST BIOL, DEPT ZOOL, BR-40170290 SALVADOR, BA, BRAZIL

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(97)00163-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new 6-hydroximino-4en-3-one steroids: (24R, 6E)-24-ethylcholest-6-hydroximino-4-en-3-one (1) and (6E) cholest-6-hydroximino-4-en-3-one (2), accompanied by the known cholest-4-en-3-one were isolated from a mixture of two morphospecies of the sponge Cinachyrella (C. alloclada and C. apion). Use of spectroscopic methods (NMR and MS) was key to establish their structures which were confirmed by synthesis. Described in this report are the fast hydroximino steroids derived from a natural source. (C) 1997 Elsevier Science Ltd.

引用

页码：1833 / 1836

页数：4

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