Perinatal exposure to high dietary advanced glycation end products in transgenic NOD8.3 mice leads to pancreatic beta cell dysfunction

被引:23
作者
Borg, Danielle J. [1 ,2 ]
Yap, Felicia Y. T. [3 ,4 ]
Keshvari, Sahar [2 ]
Simmons, David G. [5 ]
Gallo, Linda A. [1 ,5 ]
Fotheringham, Amelia K. [1 ,5 ]
Zhuang, Aowen [1 ]
Slattery, Robyn M. [4 ]
Hasnain, Sumaira Z. [2 ]
Coughlan, Melinda T. [3 ,6 ]
Kantharidis, Phillip [3 ,6 ]
Forbes, Josephine M. [1 ,3 ,7 ,8 ]
机构
[1] Univ Queensland, Mater Res Inst, Translat Res Inst, Glycat & Diabet, Brisbane, Qld, Australia
[2] Univ Queensland, Translat Res Inst, Inflammatory Dis Biol & Therapeut, Mater Res Inst, Brisbane, Qld, Australia
[3] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
[4] Monash Univ, Dept Immunol, Cent & Eastern Clin Sch, AMREP Precinct, Melbourne, Vic, Australia
[5] Univ Queensland, Sch Biomed Sci, St Lucia, Qld, Australia
[6] Monash Univ, Dept Diabet, Cent Clin Sch, Clayton, Vic, Australia
[7] Univ Queensland, Sch Med, Mater Clin Sch, St Lucia, Qld, Australia
[8] Univ Melbourne, Dept Med, Austin Hlth, Heidelberg, Vic, Australia
基金
英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;
关键词
advanced glycation end products; dietary intervention; islet; insulin; insulitis; NOD8; 3; Type; 1; diabetes; TYPE-1; DIABETES-MELLITUS; T-CELLS; INSULIN-RESISTANCE; INFLAMMATORY RESPONSE; ISLET AUTOIMMUNITY; OXIDATIVE STRESS; YOUNG AGE; COWS MILK; RISK; AUTOANTIBODIES;
D O I
10.1080/19382014.2017.1405189
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The contribution of environmental factors to pancreatic islet damage in type 1 diabetes remains poorly understood. In this study, we crossed mice susceptible to type 1 diabetes, where parental male (CD8(+) T cells specific for IGRP(206-214); NOD8.3) and female (NOD/ShiLt) mice were randomized to a diet either low or high in AGE content and maintained on this diet throughout pregnancy and lactation. After weaning, NOD8.3(+) female offspring were identified and maintained on the same parental feeding regimen for until day 28 of life. A low AGE diet, from conception to early postnatal life, decreased circulating AGE concentrations in the female offspring when compared to a high AGE diet. Insulin, proinsulin and glucagon secretion were greater in islets isolated from offspring in the low AGE diet group, which was akin to age matched non-diabetic C57BL/6 mice. Pancreatic islet expression of Ins2 gene was also higher in offspring from the low AGE diet group. Islet expression of glucagon, AGEs and the AGE receptor RAGE, were each reduced in low AGE fed offspring. Islet immune cell infiltration was also decreased in offspring exposed to a low AGE diet. Within pancreatic lymph nodes and spleen, the proportions of CD4(+) and CD8(+) T cells did not differ between groups. There were no significant changes in body weight, fasting glucose or glycemic hormones. This study demonstrates that reducing exposure to dietary AGEs throughout gestation, lactation and early postnatal life may benefit pancreatic islet secretion and immune infiltration in the type 1 diabetic susceptible mouse strain, NOD8.3.
引用
收藏
页码:10 / 24
页数:15
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