Wnt Signaling and Forebrain Development

被引：126

作者：

Harrison-Uy, Susan J. ^{[1
]}

Pleasure, Samuel J. ^{[1
,2
,3
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Program Neurosci, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Program Dev Biol, San Francisco, CA 94143 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2012年 / 4卷 / 07期

关键词：

NEURAL PRECURSOR CELLS; RADIAL GLIAL-CELLS; BETA-CATENIN; CEREBRAL-CORTEX; NEURONAL DIFFERENTIATION; DORSAL TELENCEPHALON; INTERMEDIATE PROGENITORS; MAMMALIAN TELENCEPHALON; DEVELOPING NEOCORTEX; GABAERGIC NEURONS;

D O I：

10.1101/cshperspect.a008094

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Components of the Wnt signaling pathway are expressed in a tightly regulated and spatially specific manner during development of the forebrain, and Wnts are key regulators of regional forebrain identity. Wnt signaling from the cortical hem regulates the expansion and cell-type specification of the adjacent neuroepithelium and, in conjunction with Bmp, Fgf, and Shh signaling, controls dorsal-ventral forebrain patterning. Subsequently, Wnt signaling dynamically regulates the behavior of cortical progenitor cells, initially promoting the expansion of radial glia progenitor cells and later inducing neurogenesis by promoting terminal differentiation of intermediate progenitor cells. A role for Wnt signaling in cell-type specification has also been proposed.

引用

页码：1 / 11

页数：11

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