Vitamin K status of preterm infants with a prolonged prothrombin time

被引：11

作者：

Clarke, P

Mitchell, SJ

Sundaram, S

Sharma, V

Wynn, R

Shearer, MJ

机构：

[1] Hope Hosp, Neonatol Unit, Salford M6 8HD, Lancs, England

[2] St Marys Hosp, Neonatal Med Unit, Manchester M13 0JH, Lancs, England

[3] Royal Bolton Hosp, Neonatol Unit, Bolton, England

[4] Billinge Hosp, Neonatol Unit, Wigan, Lancs, England

[5] Royal Manchester Childrens Hosp, Dept Paediat Haematol, Manchester M27 1HA, Lancs, England

[6] St Thomas Hosp, Ctr Haemostasis & Thrombosis, London, England

来源：

ACTA PAEDIATRICA | 2005年 / 94卷 / 12期

关键词：

phylloquinone; PIVKA-II; premature;

D O I：

10.1080/08035250500268233

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim: To investigate the vitamin K status of preterm infants who have a prolonged prothrombin time (PT) in the first month of life. Methods: Measures of vitamin K status were assessed in 21 preterm infants who were found to have an abnormal PT, despite 0.2-0.5 mg vitamin K, prophylaxis at birth. Results: All infants had normal or supraphysiological vitamin K, concentrations and undetectable or, in one infant, insignificant PIVKA-II, indicating adequate vitamin K status. Conclusion: In preterm infants born at < 3 2 wk gestation who received >= 0. 2 mg vitamin K-1 after delivery, a prolonged PT in the first month of life is unlikely to be due to vitamin K deficiency.

引用

页码：1822 / 1824

页数：3

共 6 条

[1]

ANDREW M, 1988, BLOOD, V72, P1651

[2] PRODUCTION OF A NEW MONOCLONAL-ANTIBODY SPECIFIC TO HUMAN DES-GAMMA-CARBOXYPROTHROMBIN IN THE PRESENCE OF CALCIUM-IONS - APPLICATION TO THE DEVELOPMENT OF A SENSITIVE ELISA-TEST [J].