From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

被引：21

作者：

Nasiripourdori, Adak ^{[2
]}

Taly, Valerie ^{[3
]}

Grutter, Thomas ^{[1
]}

Taly, Antoine ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, UMR Concept & Applicat Mol Bioact 7199, Lab Biophysicochim Recepteurs Canaux, F-67401 Illkirch Graffenstaden, France

[2] Arak Univ, Fac Sci, Dept Biol, Arak, Iran

[3] Univ Strasbourg, ISIS, Biol Chem Lab, CNRS,UMR 7006, F-67083 Strasbourg, France

来源：

TOXINS | 2011年 / 3卷 / 03期

关键词：

nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate; NICOTINIC ACETYLCHOLINE-RECEPTORS; IONOTROPIC GLUTAMATE RECEPTORS; SPIDER PHONEUTRIA-NIGRIVENTER; ALPHA-BUNGAROTOXIN BINDING; NACHR SUBTYPE SELECTIVITY; RAT HIPPOCAMPAL-NEURONS; AMINO-ACID-SEQUENCE; LUNG-CANCER; NEUROMUSCULAR-TRANSMISSION; ALPHA-7-NICOTINIC RECEPTOR;

D O I：

10.3390/toxins3030260

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.

引用

页码：260 / 293

页数：34

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