From Toxins Targeting Ligand Gated Ion Channels to Therapeutic Molecules

被引：21
作者：
Nasiripourdori, Adak [2 ]
Taly, Valerie [3 ]
Grutter, Thomas [1 ]
Taly, Antoine [1 ]
机构：
[1] Univ Strasbourg, CNRS, UMR Concept & Applicat Mol Bioact 7199, Lab Biophysicochim Recepteurs Canaux, F-67401 Illkirch Graffenstaden, France
[2] Arak Univ, Fac Sci, Dept Biol, Arak, Iran
[3] Univ Strasbourg, ISIS, Biol Chem Lab, CNRS,UMR 7006, F-67083 Strasbourg, France
来源：
TOXINS | 2011年 / 3卷 / 03期
关键词：
nAChR; P2X; GABA; Glycine; Serotonin; NMDA; AMPA; Kainate; NICOTINIC ACETYLCHOLINE-RECEPTORS; IONOTROPIC GLUTAMATE RECEPTORS; SPIDER PHONEUTRIA-NIGRIVENTER; ALPHA-BUNGAROTOXIN BINDING; NACHR SUBTYPE SELECTIVITY; RAT HIPPOCAMPAL-NEURONS; AMINO-ACID-SEQUENCE; LUNG-CANCER; NEUROMUSCULAR-TRANSMISSION; ALPHA-7-NICOTINIC RECEPTOR;
D O I：
10.3390/toxins3030260
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Ligand-gated ion channels (LGIC) play a central role in inter-cellular communication. This key function has two consequences: (i) these receptor channels are major targets for drug discovery because of their potential involvement in numerous human brain diseases; (ii) they are often found to be the target of plant and animal toxins. Together this makes toxin/receptor interactions important to drug discovery projects. Therefore, toxins acting on LGIC are presented and their current/potential therapeutic uses highlighted.
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收藏
页码：260 / 293
页数：34
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