Synthesis of 6-aryl substituted 4-quinolones via Suzuki cross coupling

被引：18

作者：

Gupta, Sumanta ^{[1
]}

Ghosh, Prasanjit ^{[1
]}

Dwivedi, Seema ^{[1
]}

Das, Sajal ^{[1
]}

机构：

[1] Univ N Bengal, Dept Chem, Darjeeling 734013, India

来源：

RSC ADVANCES | 2014年 / 4卷 / 12期

关键词：

ANTITUMOR AGENTS; BIOLOGICAL EVALUATION; DERIVATIVES; INHIBITORS; 2-PHENYL-4-QUINOLONE; OPTIMIZATION; DESIGN; ACIDS;

D O I：

10.1039/c3ra45056b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convenient way to introduce aryl functionalization in the 6-position of 4-quinolones is developed via selective bromination and subsequent arylation by Suzuki cross-coupling. Ethyl 4-quinolone 3-carboxylates were subjected to selective bromination at C-6 followed by arylation under microwave irradiation that yielded the desired cross-coupling products within 5 minutes. This approach can expediently be used for library synthesis of the aryl functionalized 4-quinolone derivative, an important class of biologically active compounds.

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收藏

页码：6254 / 6260

页数：7

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