Introduction: Penile Mondor's disease (PMD) is the thrombophlebitis of the superficial dorsal vein of the penis. The patients usually feel the superficial vein of the penis like a hard rope and present with complaint of pain around this hardness. The physiopathology of this condition remains unknown; however, it is likely that vascular transection occurring after a surgical intervention or trauma caused by external compression may be triggering this condition. Case report: A 36-year-old male presented with penile indurations that felt like a hard rope for the last one week that worsened with erection. The patient was diagnosed with PMD based on the findings from the physical examination, Colored Doppler Ultrasonography (Doppler USG) of the penis, and magnetic resonance imaging (MRI). The patient was diagnosed with subacute PMD. The patient was placed on a therapy involving oral anti-aggregants, topical anti-inflammatory agents, and heparinoid creams. The patient was recommended to abstain from sex. Conclusion: The patients with penile Mondor's disease may experience anxiety and sexual dysfunction. The early recognition of the condition on the basis of clinical and radiological evidence increases the effectiveness of medical therapy and avoids surgery. In this regard, cooperation between the radiologist and the urologist is an essential component. (C) 2014 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved.