Fluorescent Light-up Probe for the Detection of Protein Aggregates

被引：11

作者：

da Silva, Raquel Nunes ^{[1
,2
,3
,4
]}

Costa, Catarina C. ^{[1
,2
]}

Santos, Maria J. G. ^{[1
,2
]}

Alves, Mariana Q. ^{[3
,4
]}

Braga, Susana S. ^{[1
,2
]}

Vieira, Sandra I. ^{[3
,4
]}

Rocha, Joao ^{[1
,5
]}

Silva, Artur M. S. ^{[1
,2
]}

Guieu, Samuel ^{[1
,2
,5
]}

机构：

[1] Univ Aveiro, Dept Chem, Campus Santiago, Aveiro, Portugal

[2] Univ Aveiro, QOPNA, Campus Santiago, Aveiro, Portugal

[3] Univ Aveiro, Dept Med Sci, Aveiro, Portugal

[4] Univ Aveiro, IBiMED, Inst Biomed, Aveiro, Portugal

[5] Univ Aveiro, CICECO, Campus Santiago, Aveiro, Portugal

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2019年 / 14卷 / 06期

关键词：

aggregation-induced emission enhancement; cyclodextrins; DNA; fluorescent probes; protein aggregates; INDUCED-EMISSION; DEGRADATION; ENHANCEMENT; DISEASES;

D O I：

10.1002/asia.201801606

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A fluorescent dye was decorated with water-soluble pyridinium groups in order to be applied in the detection of cyclodextrins or DNA. The dye displays an enhancement of its emission intensity when the internal rotations are restricted due to the formation of an inclusion complex with cyclodextrins or upon interaction with DNA. In vivo, the fluorescent probe can stain protein aggregates with a selectivity comparable to the widely used Proteostat (R).

引用

页码：859 / 863

页数：5

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