Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat

被引：66

作者：

Hong, So Hyung ^{[1
]}

Suk, Ki Tae ^{[2
]}

Choi, Sang Hyeon ^{[2
]}

Lee, Jung Wook ^{[2
]}

Sung, Ho Taik ^{[3
]}

Kim, Chang Hoon ^{[4
]}

Kim, Eun Ji ^{[5
]}

Kim, Myoung Jo ^{[6
]}

Han, Sang Hak ^{[7
]}

Kim, Moon Young ^{[8
]}

Baik, Soon Koo ^{[8
]}

Kim, Dong Joon ^{[2
]}

Lee, Gyoung-Ja ^{[9
]}

Lee, Sang-kyu ^{[10
]}

Park, Seung Ha ^{[11
]}

Ryu, Ohk Hyun ^{[2
]}

机构：

[1] Hallym Univ, Coll Med, Dept Mol Med, Chunchon 200704, South Korea

[2] Hallym Univ, Coll Med, Dept Internal Med, Chunchon 200704, South Korea

[3] Stanford Univ, Dept Biol, Stanford, CA 94305 USA

[4] SUNY Upstate Med Univ, Coll Med, Syracuse, NY 13210 USA

[5] Hallym Univ, Ctr Efficacy Assessment & Dev Funct Foods & Drugs, Chunchon 200704, South Korea

[6] Kangwon Natl Univ, Coll Agr & Life Sci, Chunchon, South Korea

[7] Hallym Univ, Coll Med, Dept Pathol, Chunchon 200704, South Korea

[8] Yonsei Univ, Wonju Coll Med, Dept Internal Med, Wonju, South Korea

[9] Korea Atom Energy Res Inst, Nucl Mat Dev Div, Taejon, South Korea

[10] Hallym Univ, Coll Med, Dept Psychiat, Chunchon 200704, South Korea

[11] Inje Univ, Coll Med, Dept Internal Med, Pusan, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2013年 / 55卷

基金：

新加坡国家研究基金会;

关键词：

Panax ginseng; Urushiol; Non-alcoholic liver fatty disease; Rats; OLETF; INNATE IMMUNE CELLS; INSULIN-RESISTANCE; HELICOBACTER-PYLORI; TUMOR XENOGRAFTS; EXTRACT; MICE; ANTIBACTERIAL; COMPONENT; GROWTH; ROLES;

D O I：

10.1016/j.fct.2013.01.022

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Anti-oxidative and immunologic effects of the Korea red ginseng (KRG; Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease (NAFLD) were evaluated. Forty-five rats (five Long-Evans Tokushima Otsuka and 40 Otsuka Long-Evans Tokushima Fatty [OLETF] rats) received chew diets for 10 months; after this period. The OLETF rats were divided into the following four groups according to diet for 2 months: NAFLD (chew), KRG (chew + KRG [200 mg/kg/day/]), urushiol (chew + urushiol [0.5 mg/kg/day]), and ursodeoxycholic acid (UDCA) (chew + UDCA [15 mg/kg/day]) groups. Liver function, lipid profiles and anti-oxidant activity of liver and serum, natural killer (NK) cell activity, and pathology were compared. In KRG and urushiol groups, the level of serum triglyceride ([302.0 +/- 70.4 and 275.2 +/- 63.8] vs. 527.7 +/- 153.3 mg/dL) were lower compared with that of NAFLD group (p<0.05). The levels of HDL-cholesterol (liver tissue: [4.8 +/- 0.2 and 4.8 +/- 0.5] vs. 4.2 +/- 0.2 mg/g) and NK cell activity ([3485 +/- 910 and 3559 +/- 910] vs. 2486 +/- 619 counts) were significantly higher than those of the NAFLD group (p<0.001). Inflammation with neutrophil infiltration was observed in only two rats in the NAFLD group. These results suggest that 2 months of oral KRG or urushiol administration improves lipid profiles and stimulates NK cell activity, while inhibiting steatohepatitis in OLEFT rats. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：586 / 591

页数：6

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