Tubercle bacilli rely on a type VII army for pathogenicity

被引：80

作者：

Stoop, Esther J. M. ^{[1
]}

Bitter, Wilbert ^{[1
]}

van der Sar, Astrid M. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Med Ctr, Dept Med Microbiol & Infect Control, NL-1081 BT Amsterdam, Netherlands

来源：

TRENDS IN MICROBIOLOGY | 2012年 / 20卷 / 10期

关键词：

mycobacteria; tuberculosis; ESX; type VII secretion; virulence; granuloma formation; MYCOBACTERIUM-BOVIS BCG; PE-PGRS PROTEINS; SECRETION SYSTEM; ESX-1; SECRETION; CALMETTE-GUERIN; GENE-CLUSTER; DNA TRANSFER; TUBERCULOSIS; VIRULENCE; ESAT-6;

D O I：

10.1016/j.tim.2012.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mycobacteria, such as the major human pathogen Mycobacterium tuberculosis, have a highly unusual and characteristic diderm cell envelope that protects them against harmful conditions. Protein secretion across this hydrophobic barrier requires specialized secretion systems. Recently, a type VII secretion (T7S) pathway has been identified that fulfills this function. Pathogenic mycobacteria have up to five different T7S systems, some of which play a crucial role in virulence. The interactions between secreted substrates and host molecules are only starting to become clear and will help in furthering our understanding of the persistence of these enigmatic pathogens. In this review, we discuss current knowledge on the role of T7S systems in mycobacterial virulence.

引用

页码：477 / 484

页数：8

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