α-Chitin nanofibrils improve inflammatory and fibrosis responses in inflammatory bowel disease mice model

被引：39

作者：

Azuma, Kazuo ^{[1
]}

Osaki, Tomohiro ^{[1
]}

Ifuku, Shinsuke ^{[2
]}

Saimoto, Hiroyuki ^{[2
]}

Tsuka, Takeshi ^{[1
]}

Imagawa, Tomohiro ^{[1
]}

Okamoto, Yoshiharu ^{[1
]}

Minami, Saburo ^{[1
]}

机构：

[1] Tottori Univ, Fac Agr, Tottori 6808553, Japan

[2] Tottori Univ, Grad Sch Engn, Tottori 6808550, Japan

来源：

CARBOHYDRATE POLYMERS | 2012年 / 90卷 / 01期

关键词：

alpha-Chitin nanofibrils; Inflammatory bowel disease; Nuclear factor kappa B; Anti-inflammatory; Anti-fibrosis; NF-KAPPA-B; ACTIVATION; COLITIS; CYTOKINES;

D O I：

10.1016/j.carbpol.2012.05.023

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We evaluated the anti-inflammatory and anti-fibrosis effects of alpha-chitin nanofibrils in a mouse model of dextran sulfate sodium (DSS)-induced acute ulcerative colitis (UC). alpha-Chitin nanofibrils decreased positive areas of nuclear factor-kappa B staining in the colon tissue (7.2 +/- 0.5%/fields in the alpha-chitin nanofibrils group vs. 10.7 +/- 0.9%/fields in the control group; p < 0.05). alpha-Chitin nanofibrils also decreased serum monocyte chemotactic protein-1 concentration in DSS-induced acute UC (24.1 +/- 7.8 pg/ml in the alpha-chitin nanofibrils group vs. 53.5 +/- 3.1 pg/ml in the control group; p < 0.05). Moreover, alpha-chitin nanofibrils suppressed the increased positive areas of Masson's trichrome staining in colon tissue (6.8 +/- 0.6%/fields in the alpha-chitin nanofibrils group vs. 10.1 +/- 0.7%/fields in the control group; p < 0.05). On the other hand, alpha-chitin powder suspension did not show these effects in DSS-induced acute UC mice model. Our results indicated that alpha-chitin nanofibrils have the anti-inflammatory effect via suppressing NF-kappa B activation and the anti-fibrosis effects in DSS-induced acute UC mice model. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：197 / 200

页数：4

共 24 条

[1] Beneficial and preventive effect of chitin nanofibrils in a dextran sulfate sodium-induced acute ulcerative colitis model [J].