T-type Calcium Channels in Cancer

被引：49

作者：

Antal, Lauren ^{[1
]}

Martin-Caraballo, Miguel ^{[1
]}

机构：

[1] Univ Maryland Eastern Shore, Sch Pharm, Dept Pharmaceut Sci, Princess Anne, MD 21853 USA

来源：

CANCERS | 2019年 / 11卷 / 02期

关键词：

T-type Ca2+ channel; cancer; proliferation; neuroendocrine differentiation; CA2+ CHANNEL; PROSTATE-CANCER; BREAST-CANCER; NEUROENDOCRINE DIFFERENTIATION; CELL-PROLIFERATION; MEMBRANE EXPRESSION; OVARIAN-CANCER; SUBUNIT; INHIBITION; ALPHA(2)DELTA;

D O I：

10.3390/cancers11020134

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although voltage-activated Ca2+ channels are a common feature in excitable cells, their expression in cancer tissue is less understood. T-type Ca2+ channels are particularly overexpressed in various cancers. Because of their activation profile at membrane potentials close to rest and the generation of a window current, T-type Ca2+ channels may regulate a variety of Ca2+-dependent cellular processes, including cell proliferation, survival, and differentiation. The expression of T-type Ca2+ channels is of special interest as a target for therapeutic interventions.

引用

页数：18

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