Cd4+ T cell matters in tumor immunity

被引：31

作者：

Velders, MP ^{[1
]}

Markiewicz, MA ^{[1
]}

Eiben, GL ^{[1
]}

Kast, WM ^{[1
]}

机构：

[1] Loyola Univ, Cardinal Bernardin Canc Ctr, Canc Immunol Program, Maywood, IL 60153 USA

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2003年 / 22卷 / 02期

关键词：

dendritic cells; suppressor T cells; T cell memory; CD4(+) T cells; tumor immunology; MHC CLASS-II; INTERFERON-INDUCIBLE PROTEIN-10; PROTECTIVE ANTITUMOR IMMUNITY; IMMATURE DENDRITIC CELLS; VIRUS-LIKE PARTICLES; ERADICATION IN-VIVO; TOXIC LYMPHOCYTES-T; IFN-GAMMA RECEPTOR; HLA-DR MOLECULES; ESTABLISHED TUMORS;

D O I：

10.1080/08830180305220

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+) T cells have been shown to be able to affect tumor growth through both direct and indirect means. In addition, a requirement has been demonstrated for CD4(+) T cells in the regulation and induction of T cell memory, and CD4(+) suppressor T cells have been identified, stressing a role for CD4(+) T cells in the induction and maintenance of antitumor immune responses. A review of the involvement of CD4(+) T cells at different stages of tumor immunity is provided, and based on these data we discuss how CD4(+) T cell response induction could be incorporated into tumor immunotherapy strategies.

引用

页码：113 / 140

页数：28

共 50 条

[21] Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity [J].

Seah, Shirley G. K. ;

Carrington, Emma M. ;

Ng, Wy C. ;

Belz, Gabrielle T. ;

Brady, Jamie L. ;

Sutherland, Robyn M. ;

Hancock, Manuela S. ;

La Gruta, Nicole L. ;

Brown, Lorena E. ;

Turner, Stephen J. ;

Zhan, Yifan ;

Lew, Andrew M. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2012, 42 (07) :1744-1754

[22] GILT: shaping the MHC class II-restricted peptidome and CD4+ T cell-mediated immunity [J].

Hastings, Karen Taraszka .

FRONTIERS IN IMMUNOLOGY, 2013, 4

[23] Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation [J].

Klein, Ludger ;

Robey, Ellen A. ;

Hsieh, Chyi-Song .

NATURE REVIEWS IMMUNOLOGY, 2019, 19 (01) :7-18

[24] Intratumoral delivery of tumor antigen-loaded DC and tumor-primed CD4+ T cells combined with agonist -GITR mAb promotes durable CD8+ T-cell-dependent antitumor immunity [J].

Liu, Zuqiang ;

Hao, Xingxing ;

Zhang, Yi ;

Zhang, Jiying ;

Carey, Cara D. ;

Falo, Louis D. ;

Storkus, Walter J. ;

You, Zhaoyang .

ONCOIMMUNOLOGY, 2017, 6 (06)

[25] CD4+ T cells in adoptive immunotherapy and the indirect mechanism of tumor rejection [J].

Cohen, PA ;

Peng, LM ;

Plautz, GE ;

Kim, JA ;

Weng, DE ;

Shu, SY .

CRITICAL REVIEWS IN IMMUNOLOGY, 2000, 20 (01) :17-56

[26] The role of CD4+ T cells in tumor and chronic viral immune responses [J].

Xie, Luoyingzi ;

Fang, Jingyi ;

Yu, Juncheng ;

Zhang, Weinan ;

He, Zhiqiang ;

Ye, Lilin ;

Wang, Huaizhi .

MEDCOMM, 2023, 4 (05)

[27] CD4+ and CD8+ T cell-dependent antiviral immunity requires STIM1 and STIM2 [J].

Shaw, Patrick J. ;

Weidinger, Carl ;

Vaeth, Martin ;

Luethy, Kevin ;

Kaech, Susan M. ;

Feske, Stefan .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (10) :4549-4563

[28] Processing of Tumor Antigen Differentially Impacts the Development of Helper and Effector CD4+ T-cell Responses [J].

Bernard, Dannie ;

Ventresca, Michael S. ;

Marshall, Laura A. ;

Evelegh, Carole ;

Wan, Yonghong ;

Bramson, Jonathan L. .

MOLECULAR THERAPY, 2010, 18 (06) :1224-1232

[29] CD4+ T Cell Help Selectively Enhances High-Avidity Tumor Antigen-Specific CD8+ T Cells [J].

Zhu, Ziqiang ;

Cuss, Steven M. ;

Singh, Vinod ;

Gurusamy, Devikala ;

Shoe, Jennifer L. ;

Leighty, Robert ;

Bronte, Vincenzo ;

Hurwitz, Arthur A. .

JOURNAL OF IMMUNOLOGY, 2015, 195 (07) :3482-3489

[30] CD4+ T cell help improves CD8+ T cell memory by retained CD27 expression [J].

Matter, Matthias S. ;

Claus, Christina ;

Ochsenbein, Adrian F. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (07) :1847-1856

← 1 2 3 4 5 →