Cd4+ T cell matters in tumor immunity

被引：30

作者：

Velders, MP ^{[1
]}

Markiewicz, MA ^{[1
]}

Eiben, GL ^{[1
]}

Kast, WM ^{[1
]}

机构：

[1] Loyola Univ, Cardinal Bernardin Canc Ctr, Canc Immunol Program, Maywood, IL 60153 USA

来源：

INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2003年 / 22卷 / 02期

关键词：

dendritic cells; suppressor T cells; T cell memory; CD4(+) T cells; tumor immunology; MHC CLASS-II; INTERFERON-INDUCIBLE PROTEIN-10; PROTECTIVE ANTITUMOR IMMUNITY; IMMATURE DENDRITIC CELLS; VIRUS-LIKE PARTICLES; ERADICATION IN-VIVO; TOXIC LYMPHOCYTES-T; IFN-GAMMA RECEPTOR; HLA-DR MOLECULES; ESTABLISHED TUMORS;

D O I：

10.1080/08830180305220

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD4(+) T cells have been shown to be able to affect tumor growth through both direct and indirect means. In addition, a requirement has been demonstrated for CD4(+) T cells in the regulation and induction of T cell memory, and CD4(+) suppressor T cells have been identified, stressing a role for CD4(+) T cells in the induction and maintenance of antitumor immune responses. A review of the involvement of CD4(+) T cells at different stages of tumor immunity is provided, and based on these data we discuss how CD4(+) T cell response induction could be incorporated into tumor immunotherapy strategies.

引用

页码：113 / 140

页数：28

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