A multifunctional mesoporous silica nanocomposite for targeted delivery, controlled release of doxorubicin and bioimaging

被引：112
作者：
Xie, Meng [1 ,2 ]
Shi, Hui [3 ]
Li, Zhen [1 ]
Shen, Haijun [1 ]
Ma, Kun [1 ]
Li, Bo [1 ]
Shen, Song [1 ]
Jin, Yi [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, Hangzhou 310058, Zhejiang, Peoples R China
[2] Jiangsu Univ, Sch Pharm, Dept Pharmaceut, Zhenjiang 212001, Peoples R China
[3] Zhejiang Med Coll, Dept Pharm, Hangzhou 310053, Zhejiang, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2013年 / 110卷
基金：
中国国家自然科学基金;
关键词：
Doxorubicin; Mesoporous silica nanoparticles; Folate; Drug delivery; Bioimaging; DRUG-DELIVERY; PARTICLE MORPHOLOGY; P-GLYCOPROTEIN; NANOPARTICLES; RESISTANCE; PACLITAXEL; MICELLES; LIGAND; SIZE;
D O I：
10.1016/j.colsurfb.2013.04.009
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
In this study, a targeting drug delivery system based on mesoporous silica nanoparticle (MSN) was successfully developed for anti-cancer drug delivery and bioimaging. Carboxyl functionalized MSN (MSN/COOH) was firstly prepared and then modified with folate as the cancer targeting moiety and a near infrared fluorescent dye as labeling segment. Folate was conjugated to MSN/COOH via functional polyethyleneglycol (PEG), constructing the vector MSN/COOH-PEG-FA. The functionalization with carboxyl caused the pore surface of the nanocarrier more negative than native MSN, which could provide attractive forces between the nanoparticles and positively charged doxorubicin hydrochloride (DOX). Meanwhile, the folate modification significantly enhanced the cellular uptake of the delivery system compared to unmodified counterparts. Furthermore, the introduction of PEG increased the water dispersibility. Besides, the modification with the near infrared fluorescent dye Cy5 made the system effective for live cell and in vivo imaging. Therefore, the Cy5-MSN/COOH-PEG-FA system could be a promising nanocarrier for simultaneous diagnosis and treatment of diseases. (c) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：138 / 147
页数：10
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