Self-assembly of amphiphilic anionic calix[4]arenes and encapsulation of poorly soluble naproxen and flurbiprofen

被引：22
|
作者：
Barbera, Lucia [1 ]
Gattuso, Giuseppe [1 ]
Kohnke, Franz H. [1 ]
Notti, Anna [1 ]
Pappalardo, Sebastiano [2 ]
Parisi, Melchiorre F. [1 ]
Pisagatti, Ilenia [1 ]
Patane, Salvatore [3 ]
Micali, Norberto [4 ]
Villari, Valentina [4 ]
机构：
[1] Univ Messina, Dipartimento Sci Chim, I-98166 Messina, Italy
[2] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
[3] Univ Messina, Dipartimento Fis & Sci Terra, I-98166 Messina, Italy
[4] CNR, IPCF, I-98158 Messina, Italy
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 23期
关键词：
DISSOCIATION-CONSTANTS; WATER; DRUG; RECOGNITION; MICELLES; SOLUBILIZATION; AGGREGATION; AMINES;
D O I：
10.1039/c5ob00703h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Supramolecular aggregates formed through the association of an amphiphilic tetra-O-butylsulfonate calix[4]arene 1 were investigated in aqueous solution by a combination of different techniques (NMR, DLS and AFM). The ability of the micellar aggregates of calixarene 1 to increase the solubility of poorly water-soluble drugs was studied.
引用
收藏
页码：6468 / 6473
页数：6
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