Chitosan microparticles as injectable scaffolds for tissue engineering

被引：60

作者：

Garcia Cruz, Dunia Mercedes ^{[2
]}

Escobar Ivirico, Jorge Luis ^{[2
]}

Gomes, Manuela M. ^{[1
,3
]}

Gomez Ribelles, Jose Luis ^{[2
,4
,5
]}

Salmeron Sanchez, Manuel ^{[2
,4
,5
]}

Reis, Rui L. ^{[1
,3
]}

Mano, Joao F. ^{[1
,3
]}

机构：

[1] Univ Minho, Dept Polymer Engn, 3Bs Res Grp Biomat Biodegradables & Biomimet, P-4710057 Braga, Portugal

[2] Univ Politecn Valencia, Ctr Biomat, Valencia 46022, Spain

[3] PT Govt Associated Lab, IBB, Braga, Portugal

[4] Ctr Invest Principe Felipe, Regenerat Med Unit, Valencia 46013, Spain

[5] CIBER Bioingn Biomat & Nanomed, Valencia, Spain

来源：

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE | 2008年 / 2卷 / 06期

关键词：

chitosan microparticles; injectable scaffolds; stem cells; tissue engineering; minimally invasive surgical procedures;

D O I：

10.1002/term.106

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the morphology of GBMCs were evaluated after culture for 7 and 14 days. Our results show the feasibility of chitosan microparticles as potential injectable scaffolds for tissue engineering and regenerative medicine. Copyright (C) 2008 John Wiley & Sons, Ltd.

引用

页码：378 / 380

页数：3

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