Free Radical Scavenging and Anti-Edematogenic Activities of Essential Oil Obtained from Trichilia silvatica DC. (Meliaceae) Leaves

被引：0
|
作者：
Formagio, Anelise S. N. [1 ]
Dos Santos, Luiz A. C. [2 ]
Cardoso, Claudia A. L. [4 ]
Silva, Magaiver A. [3 ]
Zarate, Nestor A. H. [1 ]
Vieira, Maria C. [1 ]
Caramao, Elina B. [5 ]
Kassuya, Candida A. L. [3 ]
机构：
[1] Fundacao Univ Fed Grande Dourados, Fac Ciencias Agr, Dourados, MS, Brazil
[2] Fundacao Univ Fed Grande Dourados, Fac Ciencias Biol & Ambientais, Dourados, MS, Brazil
[3] Fundacao Univ Fed Grande Dourados, Fac Ciencias Saude, Dourados, MS, Brazil
[4] Univ Estadual Mato Grosso Sul, Dourados, MS, Brazil
[5] Univ Fed Rio Grande do Sul, Inst Quim, Porto Alegre, RS, Brazil
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2012年 / 31卷 / 03期
关键词：
Antioxidant activity; Anti-edematogenic activity; Essential oil; Trichilia silvatica; SESQUITERPENE LACTONE; EXTRACTS;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present study was focused in evaluating the chemical composition, the anti-edematogenic and antioxidant activities of essential oil obtained from Trichilia silvatica (EOTS) leaves. The EOTS was extracted by hydrodistillation and their analyses were performed by GC/MS. The main compounds identified in the EOTS were sesquiterpenes. Furthermore, the EOTS exhibited antioxidant and in vivo anti-inflammatory activity. The oral administration of EOTS (100 and 300 mg/kg), significantly inhibited the carrageenan (Cg) induced rat paw edema. The observed inhibitions were 54 +/- 7 and 49 +/- 6 % (100 mg/kg) for EOTS and 68 +/- 6 % and 66 +/- 11 % for dexamethasone after 2 and 4 h after Cg-injection, respectively. In conclusion, the present work showed for the first time, that the anti-inflammatory effects of essential oil seem to be mainly associated with the high levels of sesquiterpene in the leaves of this plant.
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收藏
页码：469 / 473
页数：5
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